Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3198	Brilaroxazine CAS No.1239729-06-6	Brilaroxazine (RP5603)/CAS No.1239729-06-6 is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo.	price>
R-R-3199	SB 271046 Hydrochloride CAS No.209481-24-3	SB 271046 Hydrochloride (SB 271046A)/CAS No.209481-24-3 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM).	price>
R-R-3200	Talipexole dihydrochloride CAS No.36085-73-1	Talipexole dihydrochloride (B-HT 920 dihydrochloride)/CAS No.36085-73-1 is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.	price>
R-R-3201	LY334370 CAS No.182563-08-2	LY334370/CAS No.182563-08-2 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.	price>
R-R-3202	DSP-1053 CAS No.1176326-76-3	DSP-1053/CAS No.1176326-76-3, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity.	price>
R-R-3203	5-HT2B antagonist-1 CAS No.393129-91-4	5-HT2B antagonist-1/CAS No.393129-91-4 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.	price>
R-R-3204	3-Hydroxy agomelatine CAS No.166526-99-4	3-Hydroxy agomelatine/CAS No.166526-99-4 is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>
R-R-3205	Velusetrag CAS No.866933-46-2	Velusetrag (TD-5108)/CAS No.866933-46-2 is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors.	price>
R-R-3206	Flesinoxan CAS No.98206-10-1	Flesinoxan/CAS No.98206-10-1 is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects.	price>
R-R-3207	Opiranserin hydrochloride CAS No.1440796-75-7	Opiranserin (VVZ-149) hydrochloride/CAS No.1440796-75-7, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain.	price>

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