Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3195	Ecopipam hydrochloride CAS No.190133-94-9	Ecopipam (SCH 39166) hydrochloride/CAS No.190133-94-9 is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia and obesity.	price>
R-R-3196	A-582941 dihydrochloride CAS No.848591-90-2	A-582941 dihydrochloride/CAS No.848591-90-2 is a potent, selective and brain-penetrant partial agonist of α7 nAChR, with Kis of 10.8 and 16.7 nM in rat brain membranes and human frontal cortex, respectively. A-582941 dihydrochloride also binds to human 5-HT3 receptor with a Ki of 150 nM. A-582941 has the potential for cognitive deficits associated with various neurodegenerative and psychiatric disorders research.	price>
R-R-3197	LP44 hydrochloride CAS No.824958-12-5	LP44 (hydrochloride)/CAS No.824958-12-5 is a selective 5-HT7 agonist with Ki of 0.22 nM. LP44 (hydrochloride) induces hypothermic effect in a dose-dependent manner by intracerebroventricular injection. LP44 (hydrochloride) not causes considerable hypothermic response by intraperitoneal administration.	price>
R-R-3198	Brilaroxazine CAS No.1239729-06-6	Brilaroxazine (RP5603)/CAS No.1239729-06-6 is a potent and orally active multimodal dopamine (DA)/serotonin (5-HT) modulator. Brilaroxazine is a partial agonist of dopamine (DA) D2, D3, and D4 receptors, 5-HT1A (Ki=1.5 nM) and 5-HT2A (Ki=2.5 nM), and has antagonist activity at 5-HT2B (Ki=0.19 nM), and 5-HT7 (Ki=2.7 nM) receptors. Brilaroxazine is an atypical antipsychotic agent, and has the potential to improve cognitive impairments in neuropsychiatric and neurological diseases in vivo.	price>
R-R-3199	SB 271046 Hydrochloride CAS No.209481-24-3	SB 271046 Hydrochloride (SB 271046A)/CAS No.209481-24-3 is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 9.02, 8.55, and 8.81 for rat, pig and human, respectively. SB 271046 Hydrochloride is over 200 fold selective for the 5-HT6 receptor vs 55 other receptors, binding sites and ion channels. Anticonvulsant activity (EC50=0.16 μM).	price>
R-R-3200	Talipexole dihydrochloride CAS No.36085-73-1	Talipexole dihydrochloride (B-HT 920 dihydrochloride)/CAS No.36085-73-1 is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.	price>
R-R-3201	LY334370 CAS No.182563-08-2	LY334370/CAS No.182563-08-2 is a selective 5-HT1F receptor agonist with a Ki of 1.6 nM.	price>
R-R-3202	DSP-1053 CAS No.1176326-76-3	DSP-1053/CAS No.1176326-76-3, a benzylpiperidine derivative, is a potent Serotonin Transporter (SERT) inhibitor with a Ki of 1.02 nM. DSP-1053 shows partial 5-HT1A receptor agonistic activity with a Ki of 5.05 nM. DSP-1053 has antidepressant activity.	price>
R-R-3203	5-HT2B antagonist-1 CAS No.393129-91-4	5-HT2B antagonist-1/CAS No.393129-91-4 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease.	price>
R-R-3204	3-Hydroxy agomelatine CAS No.166526-99-4	3-Hydroxy agomelatine/CAS No.166526-99-4 is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM.	price>

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