Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3205	Velusetrag CAS No.866933-46-2	Velusetrag (TD-5108)/CAS No.866933-46-2 is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors.	price>
R-R-3206	Flesinoxan CAS No.98206-10-1	Flesinoxan/CAS No.98206-10-1 is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects.	price>
R-R-3207	Opiranserin hydrochloride CAS No.1440796-75-7	Opiranserin (VVZ-149) hydrochloride/CAS No.1440796-75-7, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain.	price>
R-R-3208	Dehydroaripiprazole CAS No.129722-25-4	Dehydroaripiprazole (OPC-14857)/CAS No.129722-25-4 is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole.	price>
R-R-3209	p-MPPI hydrochloride CAS No.220643-77-6	p-MPPI hydrochloride/CAS No.220643-77-6 is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects.	price>
R-R-3210	Deramciclane CAS No.120444-71-5	Deramciclane/CAS No.120444-71-5 has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist.	price>
R-R-3211	Arotinolol CAS No.68377-92-4	Arotinolol/CAS No.68377-92-4 is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases.	price>
R-R-3212	Valerenic acid CAS No.3569-10-6	Valerenic acid ((-)-Valerenic Acid)/CAS No.3569-10-6, a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties.	price>
R-R-3213	Urapidil hydrochloride CAS No.64887-14-5	Urapidil hydrochloride/CAS No.64887-14-5 is an orally active α1-adrenoceptor antagonist and 5-HT1A receptor agonist with a pIC50 of 6.13 and 4.38 against α1- and α2-adrenoceptor, respectively. Urapidil hydrochloride shows antihypertensive effect.	price>
R-R-3214	Ecopipam hydrobromide CAS No.2587360-22-1	Ecopipam (SCH 39166) hydrobromide/CAS No.2587360-22-1 is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.	price>

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