Catalog |
name |
Description |
price |
R-R-3203 |
5-HT2B antagonist-1 CAS No.393129-91-4 |
5-HT2B antagonist-1/CAS No.393129-91-4 is an orally active 5-HT2B receptor antagonist with an IC50 value of 33.4 nM. 5-HT2B antagonist-1 can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascular disease or gastrointestinal disease. |
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R-R-3204 |
3-Hydroxy agomelatine CAS No.166526-99-4 |
3-Hydroxy agomelatine/CAS No.166526-99-4 is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM. |
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R-R-3205 |
Velusetrag CAS No.866933-46-2 |
Velusetrag (TD-5108)/CAS No.866933-46-2 is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors. |
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R-R-3206 |
Flesinoxan CAS No.98206-10-1 |
Flesinoxan/CAS No.98206-10-1 is a hypotensive agent and a potent, high affinity and selective 5-hydroxytryptamine1A (5-HT1A) receptor agonist with an EC50 value of 24 nM. Flesinoxan also has effective anxiolytic/antidepressant effects. |
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R-R-3207 |
Opiranserin hydrochloride CAS No.1440796-75-7 |
Opiranserin (VVZ-149) hydrochloride/CAS No.1440796-75-7, a non-opioid and non-NSAID analgesic candidate, is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. Opiranserin hydrochloride shows antagonistic activity on rP2X3 (IC50=0.87 μM). Opiranserin hydrochloride is development as an injectable agent for the treatment of postoperative pain. |
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R-R-3208 |
Dehydroaripiprazole CAS No.129722-25-4 |
Dehydroaripiprazole (OPC-14857)/CAS No.129722-25-4 is an active metabolite of Aripiprazole. Aripiprazole is an antipsychotic agent and is metabolized by CYP3A4 and CYP2D6 forming mainly Dehydroaripiprazole. Dehydroaripiprazole has with antipsychotic activity equivalent to Aripiprazole. |
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R-R-3209 |
p-MPPI hydrochloride CAS No.220643-77-6 |
p-MPPI hydrochloride/CAS No.220643-77-6 is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects. |
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R-R-3210 |
Deramciclane CAS No.120444-71-5 |
Deramciclane/CAS No.120444-71-5 has a high affinity for 5-HT2A and 5-HT2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT2C receptors without direct stimulatory agonist. |
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R-R-3211 |
Arotinolol CAS No.68377-92-4 |
Arotinolol/CAS No.68377-92-4 is a nonselective α/β-adrenergic receptor blocker and a vasodilating β-blocker. Arotinolol also shows potency for inhibiting the binding of the radioligand 125I-ICYP to 5HT1B-serotonergic receptor sites. Arotinolol is an antihypertensive agent for the treatment of a variety of cardiovascular pathologies as well as non-cardiovascular diseases. |
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R-R-3212 |
Valerenic acid CAS No.3569-10-6 |
Valerenic acid ((-)-Valerenic Acid)/CAS No.3569-10-6, a sesquiterpenoid, is an orally active positive allosteric modulator of GABAA receptors. Valerenic acid is also a partial agonist of the 5-HT5a receptor. Valerenic acid mediates anxiolytic activity via GABAA receptors containing the β3 subunit. Valerenic acid also exhibits potent antioxidant properties. |
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