Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3223	Quipazine dimaleate CAS No.150323-78-7	Quipazine dimaleate/CAS No.150323-78-7 is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.	price>
R-R-3224	Desmethyl cariprazine CAS No.839712-15-1	Desmethyl cariprazine/CAS No.839712-15-1 is an active metabolite of Cariprazine. Cariprazine, an antipsychotic agent candidate, exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (2.6 nM).	price>
R-R-3225	Frovatriptan succinate hydrate CAS No.158930-17-7	Frovatriptan succinate hydrate ((R)-Frovatriptan succinate hydrate)/CAS No.158930-17-7 is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate hydrate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate hydrate has the potential for migraine research.	price>
R-R-3226	Fananserin CAS No.127625-29-0	Fananserin (RP 62203)/CAS No.127625-29-0 is an orally bioavailable, potent and selective 5-hydroxytryptamine2 (5-HT2) receptor antagonist, with a Ki of 0.37 nM for the rat 5-HT2A receptor. Fananserin also is a selective dopamine D4 receptor antagonist, with a Ki of 2.93 nM for the human dopamine D4 receptor.	price>
R-R-3227	RS-102221 hydrochloride CAS No.187397-18-8	RS-102221 hydrochloride/CAS No.187397-18-8 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 hydrochloride shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 hydrochloride can promote the differentiation of new nerve cells. RS-102221 hydrochloride increases food-intake and weight-gain in rats.	price>
R-R-3228	Bemesetron CAS No.40796-97-2	Bemesetron (MDL 72222)/CAS No.40796-97-2 is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM. Neuroprotective effect.	price>
R-R-3229	Altanserin CAS No.76330-71-7	Altanserin/CAS No.76330-71-7 can synthesize Fluorine-18 Altanserin. Fluorine-18 Altanserin binds to the brain 5HT2 receptors.	price>
R-R-3230	Agomelatine-d6 CAS No.1079389-42-6	Agomelatine-d6/CAS No.1079389-42-6 is deuterium labeled Agomelatine. Agomelatine is a specific agonist of MT1 and MT2 receptors .	price>
R-R-3231	SB-203186 hydrochloride CAS No.207572-69-8	SB-203186 hydrochloride/CAS No.207572-69-8 is a potent, selective and competitive 5-HT4 antagonist. SB-203186 hydrochloride antagonizes the 5-HT4 receptor-mediated relaxations of the carbachol-contracted rat isolated oesophagus against 5-HT with pKB values of 10.9 (rat oesophagus), 9.5 (guinea-pig ileum), and 9.0 (human colon) respectively.	price>
R-R-3232	VUF10166 CAS No.155584-74-0	VUF10166/CAS No.155584-74-0 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB). VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM.	price>

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