Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3235	CP-809101 hydrochloride CAS No.1215721-40-6	CP-809101 hydrochloride/CAS No.1215721-40-6 is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence.	price>
R-R-3236	Ramosetron Hydrochloride CAS No.132907-72-3	Ramosetron Hydrochloride(YM060 Hydrochloride)/CAS No.132907-72-3 is a serotonin 5-HT3 receptor antagonist for the treatment of nausea and vomiting.	price>
R-R-3237	Idalopirdine Hydrochloride CAS No.467458-02-2	Idalopirdine Hydrochloride (Lu AE58054 Hydrochloride)/CAS No.467458-02-2 is a potent, selective 5-HT6 receptor antagonist with a Ki value of 0.83 nM. Idalopirdine Hydrochloride may be used in studies of schizophrenia, among other related disorders.	price>
R-R-3238	cis-Urocanic acid CAS No.7699-35-6	cis-Urocanic acid/CAS No.7699-35-6 is a 5-HT2A receptor agonist. cis-Urocanic acid binds to 5-HT receptor with relatively high affinity (Kd=4.6 nM). cis-Urocanic acid is an immune modulator that induces immunosuppression by binding to the 5-HT2A receptor.	price>
R-R-3239	Cinanserin hydrochloride CAS No.54-84-2	Cinanserin hydrochloride (SQ 10643)/CAS No.54-84-2 is a potent, selective and highly affinity 5-HT2 receptor antagonist with a Ki of 41 nM. Cinanserin hydrochloride has a much higher binding affinity for the 5-HT2 than for the 5-HT1 receptor (Ki of 3500 nM). Cinanserin is also an inhibitor of 3C-like proteinase of severe acute respiratory syndrome coronavirus and strongly reduces virus replication in vitro.	price>
R-R-3240	Masupirdine mesylate CAS No.1791396-46-7	Masupirdine mesylate (SUVN-502 mesylate)/CAS No.1791396-46-7 is a potent, selective, orally bioavailable, and brain penetrant 5-HT6 receptor antagonist (Ki of 2.04 nM for human 5-HT6 receptor). Masupirdine mesylate (SUVN-502 mesylate) shows high selectivity over 5-HT2A receptor and other 100 target sites.	price>
R-R-3241	Brexpiprazole S-oxide-d8 CAS No.2748605-29-8	Brexpiprazole S-oxide-d8/CAS No.2748605-29-8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.	price>
R-R-3242	Ro60-0175 CAS No.169675-08-5	Ro60-0175/CAS No.169675-08-5 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces self-administration.	price>
R-R-3243	PRX-07034 hydrochloride CAS No.903580-39-2	PRX-07034 hydrochloride/CAS No.903580-39-2 is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility.	price>
R-R-3244	Agomelatine hydrochloride CAS No.1176316-99-6	Agomelatine hydrochloride (S-20098 hydrochloride)/CAS No.1176316-99-6 is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.	price>

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