Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3250	Norfluoxetine hydrochloride CAS No.57226-68-3	Norfluoxetine hydrochloride/CAS No.57226-68-3 is an active N-demethylated metabolite of Fluoxetine. Fluoxetine is a selective serotonin (5-HT) reuptake inhibitor that is metabolized to Norfluoxetine hydrochloride by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. Norfluoxetine hydrochloride inhibits 5-HT uptake and inhibits CaV3.3 T current (IC50 = 5 μM). Norfluoxetine hydrochloride has anticonvulsant activity.	price>
R-R-3251	Didesmethyl cariprazine CAS No.839712-25-3	Didesmethyl cariprazine/CAS No.839712-25-3 is a metabolite of Cariprazine and acts as the predominant circulating active moiety. Didesmethyl cariprazine has a long half-life of 1-3 weeks. Cariprazine is a antipsychotic agent candidate that exhibits high affinity for the D3 and D2 receptors, and moderate affinity for the 5-HT1A receptor.	price>
R-R-3252	SB-616234-A CAS No.908601-49-0	SB-616234-A/CAS No.908601-49-0 is a selective and orally bioavailable 5-HT1B receptor antagonist, with anxiolytic and antidepressant activity.	price>
R-C-1553	Bay 59-3074 CAS:406205-74-1	Bay 59-3074 is a selective cannabinoid CB1/CB2 receptor partial agonist with Ki of 55.4 nM,48.3 nM and 45.5nM at rat and human CB1 and human CB2 receptors, respectively.Bay 59-3074 displays analgesic properties.	price>
R-R-3253	Spiramide CAS No.510-74-7	Spiramide (AMI-193)/CAS No.510-74-7 is a potent and selective antagonist of 5-HT2 and dopamine D2 receptor, with Kis of 2 nM and 3 nM, respectively. Spiramide has >2000-fold selectivity for 5-HT2 versus 5-HT1C (Ki=4300 nM) receptors. Spiramide exhibits antipsychotic activity.	price>
R-R-3254	Cerlapirdine CAS No.925448-93-7	Cerlapirdine (SAM-531, PF-05212365)/CAS No.925448-93-7 is a selective and potent full antagonist of the 5-hydroxytryptamine 6 (5-HT6) receptor.	price>
R-R-3255	Usmarapride CAS No.1428862-33-2	Usmarapride (SUVN-D4010)/CAS No.1428862-33-2 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-R-3256	Usmarapride free base CAS No.1428862-32-1	Usmarapride (SUVN-D4010) free base/CAS No.1428862-32-1 is a potent, selective, orally active and brain penetrant 5-HT4 receptor partial agonist (EC50=44 nM).	price>
R-R-3257	Ampreloxetine CAS No.1227056-84-9	Ampreloxetine (TD-9855)/CAS No.1227056-84-9 is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine has the potential for the research of neurogenic orthostatic hypotension.	price>
R-R-3258	Amitriptyline-d6 hydrochloride CAS No.203645-63-0	Amitriptyline-d6 (hydrochloride)/CAS No.203645-63-0 is the deuterium labeled Amitriptyline hydrochloride. Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>

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