Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3269	Perospirone hydrochloride CAS No.129273-38-7	Perospirone hydrochloride (SM-9018)/CAS No.129273-38-7 is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>
R-R-3270	Urapidil CAS No.34661-75-1	Urapidil/CAS No.34661-75-1 is an α1 adrenoreceptor antagonist and a 5-HT1A receptor agonist.	price>
R-R-3271	RS 67333 hydrochloride CAS No.168986-60-5	RS 67333 hydrochloride/CAS No.168986-60-5 is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors.	price>
R-R-3272	Naronapride CAS No.860174-12-5	Naronapride (ATI-7505)/CAS No.860174-12-5 is a potent prokinetic 5-HT4 receptor agonist. Naronapride can be used for gastrointestinal diseases research.	price>
R-R-3273	Amitriptyline-d3 hydrochloride CAS No.342611-00-1	Amitriptyline-d3 hydrochloride/CAS No.342611-00-1 is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with Kis of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a Ki of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity.	price>
R-R-3274	l-Pindolol CAS No.26328-11-0	l-Pindolol ((-)-pindolol)/CAS No.26328-11-0 is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease.	price>
R-R-3275	Pipamperone CAS No.1893-33-0	Pipamperone (Floropipamide; McN-JR 3345; R 3345)/CAS No.1893-33-0 is a high-affinity antagonist of 5-HT2A receptor (pKi=8.2) and D4 receptor (pKi=8.0) and a low-affinity antagonist of D2 receptor (pKi=6.7).	price>
R-R-3276	Org-12962 CAS No.132834-56-1	Org-12962/CAS No.132834-56-1 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.	price>
R-R-3277	Spiroxatrine CAS No.1054-88-2	Spiroxatrine (R 5188)/CAS No.1054-88-2 is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.	price>
R-C-1578	JK184 CAS:315703-52-7	JK-184 is a potent downstream hedgehog(Hh)signaling inhibitor that prevents Gli-dependent transcriptional activity(IC50=30nM).JK184 can specially inhibit Gli in the Hedgehog(Hh)pathway,which showed great promise for cancer therapeutics.	price>

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