Product apis-gpcr-g-protein

Home > products > apis> gpcr-g-protein

Catalog	name	Description	price
R-R-3277	Spiroxatrine CAS No.1054-88-2	Spiroxatrine (R 5188)/CAS No.1054-88-2 is a selective, dual antagonist of 5-HT1α and α2-adrenergic, with the Ki values of 3.94, 224000, 118.5 nM for 5-HT1α, 5-HT1β and 5-HT2, respectively. Spiroxatrine (R 5188) has a sedative effect.	price>
R-C-1578	JK184 CAS:315703-52-7	JK-184 is a potent downstream hedgehog(Hh)signaling inhibitor that prevents Gli-dependent transcriptional activity(IC50=30nM).JK184 can specially inhibit Gli in the Hedgehog(Hh)pathway,which showed great promise for cancer therapeutics.	price>
R-R-3278	LY-272015 hydrochloride CAS No.172895-15-7	LY-272015 hydrochloride/CAS No.172895-15-7 is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats.	price>
R-R-3279	(E)-3,4,5-Trimethoxycinnamic acid CAS No.20329-98-0	(E)-3,4,5-Trimethoxycinnamic acid (TMCA)/CAS No.20329-98-0 is a cinnamic acid substituted by multi-methoxy groups. (E)-3,4,5-Trimethoxycinnamic acid is an orally active and potent GABAA/BZ receptor agonist. (E)-3,4,5-Trimethoxycinnamic exhibits favourable binding affinity to 5-HT2C and 5-HT1A receptor, with IC50 values of 2.5 and 7.6 μM, respectively. (E)-3,4,5-Trimethoxycinnamic acid shows anticonvulsant and sedative activity. (E)-3,4,5-Trimethoxycinnamic acid can be used for the research of insomnia, headache and epilepsy.	price>
R-R-3280	YM348 CAS No.372163-84-3	YM348/CAS No.372163-84-3 is a potent and orally active 5-HT2C receptor agonist, which shows a high affinity for cloned human 5-HT2C receptor (Ki: 0.89 nM).	price>
R-R-3281	ST1936 CAS No.1210-81-7	ST1936/CAS No.1210-81-7 is a selective, nanomolar affinity 5-HT6 receptor agonist with Ki values of 13 nM, 168 nM and 245 nM for human 5-HT6, 5-HT7 and 5-HT2B receptors, respectively. ST1936 also shows moderate affinity (Ki of 300 nM) for human and rat α2 adrenergic receptor.	price>
R-C-1581	NU7026 CAS:154447-35-5	NU7026(LY293646)is a potent DNA-PK inhibitor with IC50 of 0.23 μM in cell-free assays,60-fold selective for DNA-PK than PI3K and inactive against both ATM and ATR.NU7026 enhances G2/M cell arrest and apoptosis.	price>
R-R-3282	(S)-Mirtazapine CAS No.61337-87-9	(S)-Mirtazapine ((S)-Org3770)/CAS No.61337-87-9 is a S(+)-enantiomer of Mirtazapine with pronociceptive properties in an animal model of acute thermal nociception. (S)-Mirtazapine is a stereoselective 5-HT2 receptor antagonist. (S)-Mirtazapine is metabolized by CYP2D6 and CYP1A2.	price>
R-R-3283	Repinotan hydrochloride CAS No.144980-77-8	Repinotan hydrochloride (BAY x 3702)/CAS No.144980-77-8 is a potent, selective, brain-penetrant and orally active 5-HT1A receptor agonist, with Ki values of 0.19 nM (calf hippocampus), 0.25 nM (rat and human cortex), and 0.59 nM (rat hippocampus Repinotan hydrochloride has a weak affinity for other related receptors. Repinotan hydrochloride has pronounced neuroprotective effects.	price>
R-R-3284	Clothiapine CAS No.2058-52-8	Clothiapine/CAS No.2058-52-8, an atypical antipsychotic agent, shares with clozapine its strong antiserotonergic properties.	price>

...

163