Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3287	Ampreloxetine TFA	Ampreloxetine (TD-9855) TFA is a potent and orally active norepinephrine (NE) and serotonin 5-HT inhibitor. Ampreloxetine TFA has the potential for the research of neurogenic orthostatic hypotension.	price>
R-R-3288	BRL-15572 dihydrochloride CAS No.193611-72-2	BRL-15572 dihydrochloride/CAS No.193611-72-2 is a selective antagonist of h5-HT1D, displays high affinity for h5-HT1D receptors. BRL-15572 dihydrochloride could be useful pharmacological agents to characterise 5-HT1D receptor mediated responses.	price>
R-R-3289	Quetiapine-d4 fumarate CAS No.1287376-15-1	Quetiapine-d4 (fumarate)/CAS No.1287376-15-1 is the deuterium labeled Quetiapine fumarate. Quetiapine fumarate is a 5-HT receptors agonist and a dopamine receptor antagonist. Antidepressant and anxiolytic effects.	price>
R-R-3290	Buspirone CAS No.36505-84-7	Buspirone/CAS No.36505-84-7 is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research.	price>
R-R-3291	Rodatristat CAS No.1673568-73-4	Rodatristat (KAR5417)/CAS No.1673568-73-4 is a potent tryptophan hydroxylase 1 (TPH1) and TPH2 inhibitor with IC50s value of 33 nM and 7 nM, respectively, and shows robust reduction of intestinal serotonin (5-HT) levels in mice.	price>
R-R-3292	Rodatristat ethyl CAS No.1673571-51-1	Rodatristat ethyl (KAR5585)/CAS No.1673571-51-1 is a first-in-class oral tryptophan hydroxylase 1 (TPH1) Inhibitor with nanomolar in vitro potency. Rodatristat ethyl reduces the level of 5-HT and significantly reduces pulmonary arterial hypertension (PAH).	price>
R-R-3293	Risperidone-d4 CAS No.1020719-76-9	Risperidone-d4/CAS No.1020719-76-9 is the deuterium labeled Risperidone. Risperidone is a serotonin 5-HT2 receptor blocker, P-Glycoprotein inhibitor and potent dopamine D2 receptor antagonist, with Kis of 4.8, 5.9 nM for 5-HT2A and dopamine D2 receptor, respectively.	price>
R-R-3294	Cariprazine-d6 CAS No.1308278-67-2	Cariprazine-d6/CAS No.1308278-67-2 is a deuterium labeled Cariprazine. Cariprazine Cariprazine is an antipsychotic agent that exhibits high affinity for the D3 (Ki of 0.085 nM) and D2 (Ki of 0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki of 2.6 nM).	price>
R-R-3295	Spiperone hydrochloride CAS No.2022-29-9	Spiperone hydrochloride (Spiroperidol hydrochloride)/CAS No.2022-29-9 is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.	price>
R-R-3296	BIMU 8 CAS No.134296-40-5	BIMU 8/CAS No.134296-40-5 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.	price>

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