Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3295	Spiperone hydrochloride CAS No.2022-29-9	Spiperone hydrochloride (Spiroperidol hydrochloride)/CAS No.2022-29-9 is a selective dopamine D2 receptor (Ki values of 0.06 nM, 0.6 nM, 0.08 nM, ~350 nM, ~3500 nM for D2, D3, D4, D1 and D5 receptors, respectively) and 5-HT2A/5-HT1A receptor (Kis of 1 nM/49 nM) antagonist. Spiperone hydrochloride is also a selective α1B-adrenoceptor antagonist. Spiperone hydrochloride activates calcium-activated chloride channel (CaCC). Antipsychotic and anti-inflammatory activities.	price>
R-R-3296	BIMU 8 CAS No.134296-40-5	BIMU 8/CAS No.134296-40-5 is a potent and selective 5-HT4 agonist with EC50s of 18 nM, 77 nM, and 540 nM for wild type 5HT4 receptor, T3.36A, and W6.48A mutant 5-HT4 receptors.	price>
R-R-3297	PF-04995274 CAS No.1331782-27-4	PF-04995274/CAS No.1331782-27-4 is a potent, high-affinity, orally active and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM), and has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S).	price>
R-R-3298	LP 12 hydrochloride hydrate	LP 12 hydrochloride hydrate is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively).	price>
R-R-3299	Temanogrel CAS No.887936-68-7	Temanogrel/CAS No.887936-68-7 is a highly selective 5-HT2A receptor antagonist with a Ki of 4.9 nM.	price>
R-C-1600	ozanimod CAS:1306760-87-1	Ozanimod(RPC-1063)is a potent and selective S1P1 and S1P5 receptor agonist with EC50s of 410 pM and 11 nM in [35S]-GTPγS binding,respectively.	price>
R-R-3300	Cariprazine-d8 CAS No.1308278-50-3	Cariprazine-d8/CAS No.1308278-50-3 is a deuterium labeled Cariprazine. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).	price>
R-R-3301	GR127935 hydrochloride CAS No.148642-42-6	GR127935 hydrochloride/CAS No.148642-42-6 is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research.	price>
R-C-1602	Tolvaptan CAS:150683-30-0	Tolvaptan(OPC-41061)is an orally effective nonpeptide arginine vasopressin V2 receptor antagonist with IC50 of 3 nM,used to treat hyponatremia.	price>
R-R-3302	Trazodone CAS No.19794-93-5	Trazodone (AF-1161 free base)/CAS No.19794-93-5 is a serotonin receptor antagonist and reuptake inhibitor. Trazodone can be used for the research of major depressive disorder. Trazodone also has potential for sleep disorder research.	price>

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