Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3241	Brexpiprazole S-oxide-d8 CAS No.2748605-29-8	Brexpiprazole S-oxide-d8/CAS No.2748605-29-8 is a deuterium labeled Brexpiprazole S-oxide. Brexpiprazole S-oxide is a main metabolite of Brexpiprazole and is metabolized by cytochrome P450 3A4 (CYP3A4). Brexpiprazole is an atypical antipsychotic agent and a partial agonist of human 5-HT1A and dopamine receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM.	price>
R-R-3242	Ro60-0175 CAS No.169675-08-5	Ro60-0175/CAS No.169675-08-5 is a potent and selective agonist of 5-HT2C receptor. Ro60-0175 reduces self-administration.	price>
R-R-3243	PRX-07034 hydrochloride CAS No.903580-39-2	PRX-07034 hydrochloride/CAS No.903580-39-2 is a highly selective and potent 5-HT6 receptor antagonist with a Ki= 4-8 nM and an IC50 of 19 nM. PRX-07034 can be used for the research of enhancing working memory and cognitive flexibility.	price>
R-R-3244	Agomelatine hydrochloride CAS No.1176316-99-6	Agomelatine hydrochloride (S-20098 hydrochloride)/CAS No.1176316-99-6 is a specific agonist of MT1 and MT2 receptors with Kis of 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2, respectively. Agomelatine hydrochloride is a selective 5-HT2C receptor antagonist with pKis of 6.4 and 6.2 at native (porcine) and cloned, human 5-HT2C receptors, respectively.	price>
R-R-3245	5-HT1A modulator 2 hydrochloride CAS No.3880-76-0	5-HT1A modulator 2 hydrochloride/CAS No.3880-76-0, a derivative of 8-OH-DPAT (HY-112061), is a modulator of 5-HT1A with a Ki of 53 nM for 5-HT1A binding.	price>
R-C-1546	WAY-100635 CAS：162760-96-5	WAY-100635 was originally believed to act as a selective 5-HT1A receptor antagonist,but subsequent research showed that it also acts as potent full agonist at the D4 receptor.	price>
R-R-3246	Flumexadol CAS No.30914-89-7	Flumexadol/CAS No.30914-89-7 is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.	price>
R-R-3247	Hypidone hydrochloride CAS No.1339058-04-6	Hypidone hydrochloride (YL0919)/CAS No.1339058-04-6 is an orally active antidepressant agent with dual activity as a highly seletive 5-HT uptake blocker and an effective 5-HT1A receptor agonist (Ki=0.19 nM). Hypidone hydrochloride inhibits the uptake of [3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells with IC50s of 1.78 nM and 1.93 nM, respectively. Hypidone hydrochloride shows remarkable antidepressant effects in animal models and has the poential for the investigation of depressive disorder.	price>
R-R-3248	Myristicin CAS No.607-91-0	Myristicine/CAS No.607-91-0 is an orally bioavailable serotonin receptor antagonist and weak monoamine oxidase (MAO) inhibitor. Myristicine also exerts anti-cancer effects on gastric cancer cells by inhibiting the EGFR/ERK signaling pathway. Myristicine is the main component of nutmeg essential oil and has anti-cancer, anti-proliferative, antibacterial, anti-inflammatory and apoptosis-inducing effects. Myristicine abuse can produce hallucinogenic effects, organ damage, etc.	price>
R-R-3249	LY266097 hydrochloride CAS No.172895-39-5	LY266097 hydrochloride/CAS No.172895-39-5 is a selective 5-HT2B receptor antagonist with pKis of 7.7, 9.8, and 7.6 for 5-HT2A, 5-HT2B, 5-HT2C, respectively. 5-HT2B receptor blockade contributes to the research in depression.	price>

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