Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3183	WAY-181187 CAS No.554403-49-5	WAY-181187 (SAX-187)/CAS No.554403-49-5 is a potent and selective full 5-HT6 receptor agonist with a Ki of 2.2 nM and an EC50 of 6.6 nM. WAY181187 mediates 5-HT6 receptor-dependent signal pathways, such as cAMP, Fyn and ERK1/2 kinase, as specific agonist.	price>
R-R-3184	SB 243213 CAS No.200940-22-3	SB 243213/CAS No.200940-22-3 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range of neurotransmitter receptors, enzymes and ion channels. SB 243213 has improved anxiolytic profile and has the potential for schizophrenia and motor disorders.	price>
R-R-3185	R 59-022 hydrochloride CAS No.93076-98-3	R 59-022 (DKGI-I) hydrochloride/CAS No.93076-98-3 is a DGK inhibitor (IC50: 2.8 µM). R 59-022 hydrochloride inhibits the phosphorylation of OAG to OAPA. R 59-022 hydrochloride is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 hydrochloride potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.	price>
R-R-3186	SB-277011 hydrochloride CAS No.215804-67-4	SB-277011 hydrochloride (SB-277011A hydrochloride)/CAS No.215804-67-4 is a potent, selective, orally bioavailable and brain penetrate dopamine D3 receptor (D3R) antagonist with Ki values of 10.7 nM and 11.2 nM at rodent and human D3R, respectively. SB-277011 hydrochloride displays 80- to 100-fold selectivity over other dopamine receptors with pKis of 8.0, 6.0, <5.2, and 5.9 for D3, D2, 5-HT1B, and 5-HT1D receptors, respectively.	price>
R-R-3187	Dolasetron CAS No.115956-12-2	Dolasetron(MDL-73147)/CAS No.115956-12-2 is a serotonin 5-HT3 receptor antagonist used to treat nausea and vomiting following chemotherapy.	price>
R-R-3188	Tandospirone citrate CAS No.112457-95-1	Tandospirone citrate/CAS No.112457-95-1 is a potent and selective 5-HT1A receptor partial agonist (Ki = 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Ki values ranging from 1300-41000 nM).	price>
R-R-3189	Tropisetron Hydrochloride CAS No.105826-92-4	Tropisetron Hydrochloride (SDZ-ICS-930)/CAS No.105826-92-4 is a selective 5-HT3 receptor antagonist and α7-nicotinic receptor agonist with an IC50 of 70.	price>
R-R-3190	Nelotanserin CAS No.839713-36-9	Nelotanserin/CAS No.839713-36-9 is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.	price>
R-R-3191	Pumosetrag Hydrochloride CAS No.194093-42-0	Pumosetrag Hydrochloride (MKC-733; DDP-733)/CAS No.194093-42-0 is an orally available 5-HT3 partial agonist developed for the treatment of irritable bowel syndrome and gastroesophageal reflux disease.	price>
R-R-3192	Befiradol hydrochloride CAS No.2436760-81-3	Befiradol hydrochloride (NLX-112 hydrochloride)/CAS No.2436760-81-3 is a selective 5-HT1A receptor agonist.	price>

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