Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3169	SB 242084 dihydrochloride CAS No.1049747-87-6	SB 242084 dihydrochloride/CAS No.1049747-87-6 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.	price>
R-C-1470	MK0812 CAS:624733-88-6	MK-0812 is a potent and selective CCR2 antagonist.Chemokine(C-C motif)receptor 2(CCR2)is central for the migration of monocytes into inflamed tissues.The inhibition of CCR2 signaling represents a potential therapeutic approach for treatment of metastasis without affecting homeostatic functions.	price>
R-R-3170	F-15599 CAS No.635323-95-4	F-15599/CAS No.635323-95-4 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.	price>
R-R-3171	Latrepirdine dihydrochloride CAS No.97657-92-6	Latrepirdine dihydrochloride/CAS No.97657-92-6 is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.	price>
R-C-1472	CP544326 (Taprenepag) CAS:752187-80-7	Taprenepag(CP-544326)is a potent and selective prostaglandin EP(2)agonist with IC50s of 10 and 15 nM for human and rat EP2,respectively.Taprenepag shows selectivity for EP2 over other EP receptors(IC50s>3200 nM for EP1,EP3,and EP4)and a panel of 37G protein-coupled receptors.	price>
R-R-3172	Cyproheptadine CAS No.129-03-3	Cyproheptadine/CAS No.129-03-3 is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders.	price>
R-C-1473	ZM241385 CAS:139180-30-6	ZM-241385 is a potent and highly selective Adenosine A2A-R antagonist,with a pA2 of 9.02 for Adenosine A2A-R in cardiac vasculature and selectivities of 1000,91 and 500,000 over Adenosine A1-R,Adenosine A2B-R and Adenosine A3-R sites, respectively.	price>
R-R-3173	JNJ-18038683 CAS No.851376-05-1	JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.	price>
R-R-3174	Ocaperidone CAS No.129029-23-8	Ocaperidone/CAS No.129029-23-8 is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.	price>
R-R-3175	Phenylbiguanide CAS No.102-02-3	Phenylbiguanide/CAS No.102-02-3 is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.	price>

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