Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-C-1470	MK0812 CAS:624733-88-6	MK-0812 is a potent and selective CCR2 antagonist.Chemokine(C-C motif)receptor 2(CCR2)is central for the migration of monocytes into inflamed tissues.The inhibition of CCR2 signaling represents a potential therapeutic approach for treatment of metastasis without affecting homeostatic functions.	price>
R-R-3170	F-15599 CAS No.635323-95-4	F-15599/CAS No.635323-95-4 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.	price>
R-R-3171	Latrepirdine dihydrochloride CAS No.97657-92-6	Latrepirdine dihydrochloride/CAS No.97657-92-6 is a neuroactive compound with antagonist activity at histaminergic, α-adrenergic, and serotonergic receptors. Latrepirdine stimulates amyloid precursor protein (APP) catabolism and amyloid-β (Aβ) secretion.	price>
R-C-1472	CP544326 (Taprenepag) CAS:752187-80-7	Taprenepag(CP-544326)is a potent and selective prostaglandin EP(2)agonist with IC50s of 10 and 15 nM for human and rat EP2,respectively.Taprenepag shows selectivity for EP2 over other EP receptors(IC50s>3200 nM for EP1,EP3,and EP4)and a panel of 37G protein-coupled receptors.	price>
R-R-3172	Cyproheptadine CAS No.129-03-3	Cyproheptadine/CAS No.129-03-3 is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders.	price>
R-C-1473	ZM241385 CAS:139180-30-6	ZM-241385 is a potent and highly selective Adenosine A2A-R antagonist,with a pA2 of 9.02 for Adenosine A2A-R in cardiac vasculature and selectivities of 1000,91 and 500,000 over Adenosine A1-R,Adenosine A2B-R and Adenosine A3-R sites, respectively.	price>
R-R-3173	JNJ-18038683 CAS No.851376-05-1	JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.	price>
R-R-3174	Ocaperidone CAS No.129029-23-8	Ocaperidone/CAS No.129029-23-8 is an effective antipsychotic agent, acting as a potent 5-HT2 and dopamine D2 antagonist, and a 5-HT1A agonist, with Kis of 0.14 nM, 0.46 nM, 0.75 nM, 1.6 nM and 5.4 nM for 5-HT2, a1-adrenergic receptor, dopamine D2, histamine H1 and a2-adrenergic receptor, respectively, and a pEC50 and pKi of 7.60 and 8.08 for h5-HT1A.	price>
R-R-3175	Phenylbiguanide CAS No.102-02-3	Phenylbiguanide/CAS No.102-02-3 is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.	price>
R-C-1476	MK-3697 CAS:1224846-01-8	MK-3697 is a highly potent,orally bioavailable selective orexin 2 receptor antagonists.MK-3697 is also the third insomnia drug,currently being developed by Merck.MK-3697 has Ki=0.95nM.Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia.In vivo tests results on MK-3697 demonstrated improved stability and TDI profiles as well as excellent sleep efficacy across species.	price>

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