Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3160	Ziprasidone hydrochloride monohydrate CAS No.138982-67-9	Ziprasidone (CP-88059) hydrochloride monohydrate/CAS No.138982-67-9 is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone hydrochloride monohydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).	price>
R-R-3161	Jatrorrhizine hydroxide CAS No.483-43-2	Jatrorrhizine hydroxide/CAS No.483-43-2 is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters.	price>
R-R-3162	Gepirone CAS No.83928-76-1	Gepirone/CAS No.83928-76-1 is a selective and affinitive 5-HT1A agonist. Gepirone binds selectively to 5-HT1A receptor binding site. Gepirone acts as an antidepressant agent can be used for anxiety and major depressive disorder research.	price>
R-R-3163	Asenapine CAS No.65576-45-6	Asenapine (Org 5222)/CAS No.65576-45-6, an atypical antipsychotic, is an antagonist of serotonin receptors (pKi: 8.4-10.5), adrenoceptors (pKi: 8.9-9.5), dopamine receptors (pKi: 8.9-9.4) and histamine receptors (pKi: 8.2-9.0). Asenapine can be used in the research of schizophrenia and bipolar disorder.	price>
R-R-3164	RU 24969 CAS No.66611-26-5	RU 24969/CAS No.66611-26-5 is a preferential 5-HT1B agonist, with a Ki of 0.38 nM, but also displays appreciable affinity for the 5-HT1A receptor (Ki=2.5 nM), and has low affinity for other receptor sites in the brain. RU 24969 could decrease fluid consumption and increase forward locomotion.	price>
R-R-3165	Rotigotine Hydrochloride CAS No.125572-93-2	Rotigotine Hydrochloride (N-0923 Hydrochloride)/CAS No.125572-93-2 is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.	price>
R-R-3166	Tianeptine sodium salt CAS No.30123-17-2	Tianeptine sodium salt/CAS No.30123-17-2 is a selective facilitator of 5-HT uptake. Tianeptine sodium salt has no affinity for a wide range of receptors, including 5-HT and dopamine (IC50>10 μM) and has no effect on noradrenalin or dopamine uptake. Tianeptine sodium salt has antidepressant, anxiolytic, analgesic and neuroprotective activities.	price>
R-R-3167	Rizatriptan benzoate CAS No.145202-66-0	Rizatriptan Benzoate(Maxalt)/CAS No.145202-66-0 is a 5-HT1 agonist triptan drug for the treatment of migraine headaches.	price>
R-R-3168	Nefazodone CAS No.83366-66-9	Nefazodone/CAS No.83366-66-9 is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction.	price>
R-R-3169	SB 242084 dihydrochloride CAS No.1049747-87-6	SB 242084 dihydrochloride/CAS No.1049747-87-6 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 dihydrochloride increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 dihydrochloride also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 dihydrochloride has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.	price>

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