Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3140	Rotigotine CAS No.99755-59-6	Rotigotine/CAS No.99755-59-6 is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor.	price>
R-R-3141	Granisetron Hydrochloride CAS No.107007-99-8	Granisetron (Hydrochloride) (BRL 43694A)/CAS No.107007-99-8 is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy.	price>
R-R-3142	Palonosetron hydrochloride CAS No.135729-62-3	Palonosetron hydrochloride/CAS No.135729-62-3 is a 5-HT3 antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).	price>
R-R-3143	Sarpogrelate hydrochloride CAS No.135159-51-2	Sarpogrelate hydrochloride (MCI-9042)/CAS No.135159-51-2 is a selective 5-HT2R antagonist, with pKis of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively. Sarpogrelate hydrochloride displays selectivity over 5-HT1, 5-HT3, 5-HT4, α1-, α2- and β-adrenoreceptor, histamine H1, H2 and muscarinic M3 receptors. Sarpogrelate hydrochloride can be used for the research of vascular disease associated with thrombosis.	price>
R-R-3144	Sarizotan CAS No.351862-32-3	Sarizotan (EMD 128130)/CAS No.351862-32-3 is an orally active serotonin 5-HT1A receptor and dopamine receptor agonist. Sarizotan (EMD 128130) exhibits IC50 values of 6.5 nM (rat 5-HT1A), 0.1 nM (human 5-HT1A), 15.1 nM (rat D2), 17 nM (human D2), 6.8 nM (human D3) and 2.4 nM (human D4.2), respectively.	price>
R-R-3145	Alosetron Hydrochloride CAS No.122852-69-1	Alosetron Hydrochloride (GR 68755C)/CAS No.122852-69-1 is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.	price>
R-R-3146	NAS-181 dimesylate CAS No.1217474-40-2	NAS-181 dimesylate/NAS181/CAS No.1217474-40-2 is a potent and selective antagonist of rat 5-HT1B receptor, with a Ki of 47 nM. NAS181 shows 13-fold selectivity for r5-HT1B over bovine 5-HT1B receptor (Ki=630 nM). NAS181 increases the 5-HT turnover and the synaptic concentration of 5-HT by inhibiting terminal r5-HT1B autoreceptors.	price>
R-R-3147	Spadin TFA	Spadin TFA, a natural peptide derived from a propeptide released in blood, is a potent TREK-1 channel blocker with an IC50 value of 10 nM. Spadin TFA enhances dorsal raphe nucleus 5-HT neurotransmission in mice and induces hippocampal CREB activation and neurogenesis. Spadin TFA can be used for antidepressant research.	price>
R-R-3148	Harmine hydrochloride CAS No.343-27-1	Harmine Hydrochloride (Telepathine Hydrochloride)/CAS No.343-27-1 is a natural DYRK inhibitor with anticancer and anti-inflammatory activities. Harmine has a high affinity of 5-HT2A serotonin receptor, with an Ki of 397 nM.	price>
R-R-3149	Perospirone CAS No.150915-41-6	Perospirone (SM-9018 free base)/CAS No.150915-41-6 is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.	price>

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