Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3132	Lurasidone Hydrochloride CAS No.367514-88-3	Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride))/CAS No.367514-88-3 is an antagonist of both dopamine D2 and 5-HT7 with IC50s of 1.68 and 0.495 nM, respectively. Lurasidone (Hydrochloride) (SM-13496 (Hydrochloride)) is also a partial agonist of 5-HT1A receptor with an IC50 of 6.75 nM.	price>
R-R-3133	Levomepromazine CAS No.60-99-1	Levomepromazine (Methotrimeprazine)/CAS No.60-99-1 is an orally available neuroleptic agent, which is commonly used to relieve nausea and vomiting in palliative care settings. Levomepromazine has antagonist actions at multiple neurotransmitter receptor sites, including dopaminergic, cholinergic, serotonin and histamine receptors.	price>
R-C-1434	GSK137647A CAS：349085-82-1	GSK137647A is an agonist of the free fatty acid receptor 4(FFA4/GPR120)with pEC50s=6.3,6.2,and 6.1 at human,mouse,and rat receptors,respectively.GSK137647A is selective for GPR120 over a panel of 61 other targets,including other FFARs.	price>
R-R-3134	Gamma-Mangostin CAS No.31271-07-5	Gamma-Mangostin/CAS No.31271-07-5 is a novel competitive 5-hydroxytryptamine 2A (5-HT2A) receptors antagonist, purified from the fruit hull of the medicinal plant Garcinia mangostana. Gamma-Mangostin is a inhibitor of Transthyretin (TTR) fibrillization, it binds to the thyroxine (T4)-binding sites and stabilized the TTR tetramer. Gamma-Mangostin inhibits [3H] spiperone binding to cultured rat aortic myocytes (IC50=3.5 nM) and reduces The perfusion pressure response of rat coronary artery to 5-HT2A (IC50=0.32 µM) .	price>
R-R-3135	Roluperidone CAS No.359625-79-9	Roluperidone (CYR-101)/CAS No.359625-79-9 is a novel cyclic amide derivative that has high equipotent affinities for 5-HT2A and sigma-2 receptors (Ki of 7.53 nM and 8.19 nM for 5-HT2A and sigma-2, respectively).	price>
R-R-3136	Syk Inhibitor II CAS No.726695-51-8	Syk Inhibitor II/CAS No.726695-51-8 is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect.	price>
R-R-3137	R 59-022 CAS No.93076-89-2	R 59-022 (DKGI-I)/CAS No.93076-89-2 is a DGK inhibitor (IC50: 2.8 µM). R 59-022 inhibits the phosphorylation of OAG to OAPA. R 59-022 is a 5-HT Receptor antagonist, and activates protein kinase C (PKC). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neutrophils.	price>
R-C-1438	CYM5442 CAS：1094042-01-9	CYM5442 is a potent,highly-selective and orally active sphingosine 1-phosphate (S1P1)receptor agonist with an EC50 of 1.35 nM.CYM5442 is inactive against S1P2,S1P3,S1P4,and S1P5.CYM5442 activates S1P1-dependent p42/p44-MAPK phosphorylation.CYM5442 exerts retinal neuroprotection.CYM5442 can easily penetrate the central nervous system(CNS).	price>
R-R-3138	Paliperidone palmitate CAS No.199739-10-1	Paliperidone palmitate (9-Hydroxyrisperidone palmitate)/CAS No.199739-10-1, an atypical long-acting antipsychotic agent, is an ester proagent of Paliperidone. Paliperidone is a dopamine antagonist and 5-HT2A antagonist of the atypical antipsychotic class. Paliperidone palmitate shows efficacy against schizophrenia.	price>
R-R-3139	Prucalopride succinate CAS No.179474-85-2	Prucalopride succinate/CAS No.179474-85-2 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride succinate improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride succinate also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride succinate can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>

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