Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3114	Ketanserin tartrate CAS No.83846-83-7	Ketanserin (R41468) tartrate/CAS No.83846-83-7 is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).	price>
R-R-3115	Pimavanserin hemitartrate CAS No.706782-28-7	Pimavanserin (ACP-103) hemitartrate/CAS No.706782-28-7 is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.	price>
R-R-3116	Prucalopride CAS No.179474-81-8	Prucalopride/CAS No.179474-81-8 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>
R-R-3117	8-OH-DPAT hydrobromide CAS No.76135-31-4	8-OH-DPAT (8-Hydroxy-DPAT) hydrobromide/CAS No.76135-31-4 is a potent and selective 5-HT1A agonist with a pIC50 of 8.19. 8-OH-DPAT hydrobromide has selectivity of almost 1000 fold for a subtype of the 5-HT1 binding site.	price>
R-C-1418	Siponimod (BAF312) CAS:1230487-00-9	BAF312(Siponimod)is a next-generation S1P receptor agonist,selective for S1P1 and S1P5 receptors with EC50 of 0.39 nM and 0.98 nM,exhibits >1000-fold selectivity over S1P2,S1P3 and S1P4 receptors.	price>
R-R-3118	S1RA hydrochloride CAS No.1265917-14-3	S1RA (E-52862) hydrochloride/CAS No.1265917-14-3 is an orally active and selective sigma-1 receptor (σ1R) antagonist with a Ki value of 17 nM. S1RA hydrochloride shows good selectivity against σ2R (Ki >1000 nM). S1RA hydrochloride is a human 5-HT2B receptor antagonist with an IC50 value of 4.7 μM. S1RA hydrochloride inhibits neuropathic pain and activity-induced spinal sensitization.	price>
R-R-3119	Loxapine CAS No.1977-10-2	Loxapine/CAS No.1977-10-2 is an orally active dopamine inhibitor, 5-HT receptor antagonist and also a dibenzoxazepine anti-psychotic agent.	price>
R-R-3120	Tandospirone CAS No.87760-53-0	Tandospirone (SM-3997)/CAS No.87760-53-0 is a potent and selective 5-HT1A receptor partial agonist, with a Ki of 27 nM. Tandospirone has anxiolytic and antidepressant activities. Tandospirone can be used for the research of the central nervous system disorders and the underlying mechanisms.	price>
R-R-3121	Cariprazine CAS No.839712-12-8	Cariprazine/RGH-188/CAS No.839712-12-8 is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).	price>
R-R-3122	Asenapine maleate CAS No.85650-56-2	Asenapine maleate/CAS No.85650-56-2 is a 5-HT (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) and D2 antagonist with Ki values of 0.03-4.0 nM, 1.3nM, respectively, and an antipsychotic.	price>

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