Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3101	GR 113808 CAS No.144625-51-4	GR 113808/CAS No.144625-51-4 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.	price>
R-C-1403	BMS-986020 CAS:1257213-50-5	BMS-986020(AM152,AP-3152 free acid)is a potent and selective antagonist of lysophosphatidic acid receptor 1(LPA1).BMS-986020 inhibits bile acid and phospholipid transporters with IC50 of 4.8μM,6.2 μM,and 7.5μM for BSEP,MRP4,and MDR3,respectively.BMS-986020 has the potential for the treatment of idiopathic pulmonary fibrosis(IPF).	price>
R-R-3109	Sumatriptan succinate CAS No.103628-48-4	Sumatriptan succinate (GR 43175)/CAS No.103628-48-4 is an orally active 5-HT1 receptor agonist with IC50s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT1D, 5-HT1B and 5-HT1F receptors, respectively. Sumatriptan succinate can be used for migraine headache research.	price>
R-R-3110	Ziprasidone CAS No.146939-27-7	Ziprasidone (CP-88059)/CAS No.146939-27-7, an orally active antipsychotic agent, is a combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).	price>
R-R-3111	Metergoline CAS No.17692-51-2	Metergoline/CAS No.17692-51-2 is a serotonin (5-HT) receptor and dopamine receptors antagonist, with pKis of 8.64, 8.75 and 8.75 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. Metergoline is a high-affinity ligand for the h5-HT7 receptor, with a Ki of 16 nM. Metergoline is also a reversible neural Na+ channels inhibitor. Metergoline is commonly used for the research of seasonal affective disorder, prolactin hormone regulation.	price>
R-R-3112	Spiperone CAS No.749-02-0	Spiperone/CAS No.749-02-0 is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone is a widely used pharmacological tool. Spiperone has the potential for the research of neurology diseases.	price>
R-R-3113	Mirtazapine CAS No.85650-52-8	Mirtazapine (Org3770)/CAS No.85650-52-8 is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. Mirtazapine is also a 5-HT2, 5-HT3, histamine H1 receptor and α2-adrenoceptor antagonist with pKi values of 8.05, 8.1, 9.3 and 6.95, respectively.	price>
R-R-3114	Ketanserin tartrate CAS No.83846-83-7	Ketanserin (R41468) tartrate/CAS No.83846-83-7 is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).	price>
R-R-3115	Pimavanserin hemitartrate CAS No.706782-28-7	Pimavanserin (ACP-103) hemitartrate/CAS No.706782-28-7 is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.	price>
R-R-3116	Prucalopride CAS No.179474-81-8	Prucalopride/CAS No.179474-81-8 is an orally active, selective and specific 5-HT 4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer.	price>

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