Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3124	Mosapride citrate CAS No.112885-42-4	Mosapride citrate/CAS No.112885-42-4 is an orally active gastroenterokinetic compound. Mosapride citrate is a 5HT4 agonist. Mosapride citrate is a CYP inducer. Mosapride citrate has a concentration-dependent inhibitory effect on Kv4.3, and its IC50 value is 15.2 μM. Mosapride citrate can be used in the study of gastrointestinal diseases.	price>
R-R-3125	Methiothepin mesylate CAS No.74611-28-2	Methiothepin (Metitepine) mesylate/CAS No.74611-28-2 is a potent and non-selective 5-HT2 receptor antagonist, with pKds of 7.10 (5-HT1A), 7.28 (5HT1B), 7.56 (5HT1C), 6.99 (5HT1D), 7.0 (5-HT5A), 7.8 (5-HT5B), 8.74 (5-HT6), and 8.99 (5-HT7), and pKis of 8.50 (5HT2A), 8.68 (5HT2B), and 8.35 (5HT2C).	price>
R-R-3126	SB-224289 hydrochloride CAS No.180084-26-8	SB-224289 hydrochloride/CAS No.180084-26-8 is a selective 5-HT1B receptor antagonist, with anxiolytic effect.	price>
R-R-3127	SB 204741 CAS No.152239-46-8	SB 204741/CAS No.152239-46-8 is a selective and high affinity 5-HT2B antagonist with a pKi value of 7.1.	price>
R-R-3128	RS-127445 hydrochloride CAS No.199864-86-3	RS-127445 hydrochloride/CAS No.199864-86-3 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 hydrochloride shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.	price>
R-C-1429	Talnetant CAS：174636-32-9	Talnetant is a potent and selective NK3 receptor antagonist(ki=1.4nM,hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor,with no affinity for the hNK-1 at concentrations up to 100 uM.	price>
R-R-3129	Nefazodone hydrochloride CAS No.82752-99-6	Nefazodone hydrochloride (BMY-13754)/CAS No.82752-99-6 is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity.	price>
R-C-1430	Tepoxalin CAS：174636-32-9	Talnetant(SB 223412)is a potent and selective NK3 receptor antagonist(ki=1.4nM, hNK-3-CHO);100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM.	price>
R-R-3130	Trimipramine maleate CAS No.521-78-8	Trimipramine maleate/CAS No.521-78-8 is a 5-HT receptor antagonist, with pKi binding values of 6.39, 8.10, 4.66 for 5-HT1C, 5-HT2 and 5-HT1A, respectively. Trimipramine maleate is also a potent and selective inhibitor targeting human noradrenaline (hNAT), serotonin (hSERT) and organic cation transporters (hOCT1, hOCT2) with IC50 values of 4.99 μM, 2.11 μM, 3.72 μM, 8.00 μM, respectively. Trimipramine maleate has vascular activity and anxiolytic efficacy.	price>
R-R-3131	LP-211 CAS No.1052147-86-0	LP-211/CAS No.1052147-86-0 is a selective and blood−brain barrier penetrant 5-HT7 receptor agonist, with a Ki of 0.58 nM, with high selectivity over 5-HT1A receptor (Ki, 188 nM) and D2 receptor (Ki, 142 nM).	price>

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