Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3089	Vortioxetine hydrobromide CAS No.960203-27-4	Vortioxetine hydrobromide/CAS No.960203-27-4 is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-R-3090	WAY-100635 maleate CAS No.1092679-51-0	WAY-100635 maleate/CAS No.1092679-51-0 is a potent and selective 5-hydroxytryptamine 1A (5-HT1A) receptor antagonist with an IC50 value of 0.91 nM and Ki value of 0.39 nM. WAY-100635 maleate has pIC50 values for 5-HT1A and α1-adrenergic receptors of 8.9 and 6.6, respectively. WAY-100635 maleate is also a potent dopamine D4 receptor agonist.	price>
R-R-3091	8-OH-DPAT CAS No.78950-78-4	8-OH-DPAT /CAS No.78950-78-4 is a potent and selective 5-HT agonist, with a pIC50 of 8.19 for 5-HT1A and a Ki of 466 nM for 5-HT7; 8-OH-DPAT weakly binds to 5-HT1B (pIC50, 5.42), 5-HT (pIC50 <5).	price>
R-R-3092	Quetiapine CAS No.111974-69-7	Quetiapine (ICI204636)/CAS No.111974-69-7 is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects.	price>
R-R-3093	BW-723C86 CAS No.160521-72-2	BW-723C86/CAS No.160521-72-2 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats.	price>
R-R-3094	Alprenolol hydrochloride CAS No.13707-88-5	Alprenolol ((RS)-Alprenolol; dl-Alprenolol) hydrochloride/CAS No.13707-88-5 is an orally active non-selective β-adrenoceptor antagonist and an antagonist of 5-HT1A and 5-HT1B receptors. Alprenolol hydrochloride is used as an anti-hypertensive, anti-anginal and anti-arrhythmic agent.	price>
R-R-3095	Vilazodone Hydrochloride CAS No.163521-08-2	Vilazodone Hydrochloride (EMD 68843 Hydrochloride)/CAS No.163521-08-2 is a serotonin transporter (SER) inhibitor and 5-HT1A receptor partial agonist.	price>
R-R-3096	Pimavanserin CAS No.706779-91-1	Pimavanserin/CAS No.706779-91-1 is a selective inverse agonist of the 5-HT2A receptor with pIC50 and pKd of 8.73 and 9.3, respectively.	price>
R-R-3097	SB 242084 CAS No.181632-25-7	SB 242084/CAS No.181632-25-7 is a selective, competitive and high-affinity (pKi=9.0) 5-HT2C receptor antagonist (crosses the blood-brain barrier). SB 242084 increases basal activity of dopaminergic neurons in the ventral tegmental area (VTA) of the midbrain and dopamine release in the vomeronasal nucleus. SB 242084 also increases mitochondrial gene expression and oxidative metabolism via 5-HT2A receptor. SB 242084 has good research potential in the negative symptoms of anxiety, depression and schizophrenia, as well as in acute organ damage.	price>
R-R-3098	Nuciferine CAS No.475-83-2	Nuciferine/CAS No.475-83-2 is an antagonist at 5-HT2A (IC50=478 nM), 5-HT2C (IC50=131 nM), and 5-HT2B (IC50=1 μM), an inverse agonist at 5-HT7 (IC50=150 nM), a partial agonist at D2 (EC50=64 nM), D5 (EC50=2.6 μM) and 5-HT6 (EC50=700 nM), an agonist at 5-HT1A (EC50=3.2 μM) and D4 (EC50=2 μM) receptor.	price>

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