Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3072	CCG 203769 CAS No.410074-60-1	CCG 203769/CAS No.410074-60-1 is a selective G protein signaling (RGS4) inhibitor, which blocks the RGS4-Gαo protein-protein interaction in vitro with an IC50 of 17 nM.	price>
R-R-3073	CCG-63802 CAS No.620112-78-9	CCG-63802/CAS No.620112-78-9 is a selective, reversible and allosteric RGS4 inhibitor. CCG-63802 specifically binds to RGS4 and blocks the RGS4-Gαo interaction, with an IC50 value of 1.9 μM.	price>
R-R-3074	BMS-192364 CAS No.202822-21-7	BMS-192364/CAS No.202822-21-7 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux.	price>
R-R-3075	CCG-63808 CAS No.620113-73-7	CCG-63808/CAS No.620113-73-7 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.	price>
R-R-3076	GTS-21 dihydrochloride CAS No.156223-05-1	GTS-21 dihydrochloride/CAS No.156223-05-1 is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.	price>
R-R-3077	Olanzapine CAS No.132539-06-1	Olanzapine (LY170053)/CAS No.132539-06-1 is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.	price>
R-R-3078	S-15535 CAS No.146998-34-7	S-15535/CAS No.146998-34-7 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety.	price>
R-R-3079	Clozapine CAS No.5786-21-0	Clozapine (HF 1854)/CAS No.5786-21-0 is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).	price>
R-R-3080	SB-699551 CAS No.864741-95-7	SB-699551/CAS No.864741-95-7 is a potent and selective 5-HT5A antagonist with a pKi of 8.3. SB-699551 inhibits tumorsphere formation. SB-699551 reduces phosphorylation of AKT at serine residue 473 (S473), WNK1, PRAS40. SB-699551 shows anticancer activity and has the potential for the research of breast tumor.	price>
R-C-1381	Lu AE58054 (Idalopirdine) CAS NO. 467459-31-0	Idalopirdine is a potent and selective 5-HT6 receptor antagonist for potential use in the treatment of cognitive deficits associated with Alzheimer is disease and schizophrenia.	price>

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