Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3075	CCG-63808 CAS No.620113-73-7	CCG-63808/CAS No.620113-73-7 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.	price>
R-R-3076	GTS-21 dihydrochloride CAS No.156223-05-1	GTS-21 dihydrochloride/CAS No.156223-05-1 is a selective alpha7 nicotinic acetylcholine receptor (α7-nAChR) agonist with anti‑inflammatory and cognition‑enhancing activities. GTS-21 dihydrochloride is also a α4β2 (Ki=20 nM for humanα4β2) and 5-HT3A receptor (IC50=3.1 μM) antagonist.	price>
R-R-3077	Olanzapine CAS No.132539-06-1	Olanzapine (LY170053)/CAS No.132539-06-1 is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptor (Ki=19 nM). Olanzapine is an atypical antipsychotic.	price>
R-R-3078	S-15535 CAS No.146998-34-7	S-15535/CAS No.146998-34-7 is a highly selective 5-HT1A receptor ligand. S-15535 is an antagonist of postsynaptic 5-HT1A receptors and an agonist of presynaptic 5-HT1A receptors. S-15535 can be used in research on psychiatric disorders, such as anti-anxiety.	price>
R-R-3079	Clozapine CAS No.5786-21-0	Clozapine (HF 1854)/CAS No.5786-21-0 is an antipsychotic used for the research of schizophrenia. Clozapine has high affinity for a number of neuroreceptors. Clozapine is a potent antagonist of dopamine D2 with a Ki of 75 nM. Clozapine inhibits the muscarinic M1 receptor and serotonin 5HT2A receptor with Kis of 9.5 nM and 4 nM, respectively. Clozapine is also a potent and selective agonist at the muscarinic M4 receptor (EC50=11 nM).	price>
R-R-3080	SB-699551 CAS No.864741-95-7	SB-699551/CAS No.864741-95-7 is a potent and selective 5-HT5A antagonist with a pKi of 8.3. SB-699551 inhibits tumorsphere formation. SB-699551 reduces phosphorylation of AKT at serine residue 473 (S473), WNK1, PRAS40. SB-699551 shows anticancer activity and has the potential for the research of breast tumor.	price>
R-C-1381	Lu AE58054 (Idalopirdine) CAS NO. 467459-31-0	Idalopirdine is a potent and selective 5-HT6 receptor antagonist for potential use in the treatment of cognitive deficits associated with Alzheimer is disease and schizophrenia.	price>
R-R-3081	Puerarin CAS No.3681-99-0	Puerarin/CAS No.3681-99-0, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.	price>
R-R-3082	Vortioxetine CAS No.508233-74-7	Vortioxetine/CAS No.508233-74-7 is a inhibitor of 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT, with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively.	price>
R-R-3083	Ondansetron CAS No.99614-02-5	Ondansetron (GR 38032; SN 307)/CAS No.99614-02-5 is a highly selective 5-HT3 receptor antagonist, with IC50 value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity.	price>

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