Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-C-1354	Losartan Carboxylic Acid (EXP-3174) CAS:124750-92-1	Losartan Carboxylic Acid(E-3174),an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1(AT1)antagonist.The Ki values are 0.97,0.57,0.67 nM for rat AT1B/AT1A and human AT1,respectively.Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells(VSMC).Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.	price>
R-R-3054	KRAS G12D inhibitor 1 CAS No.2621928-43-4	KRAS G12D inhibitor 1 (example 243)/CAS No.2621928-43-4 is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1355	MK7622 CAS:1227923-29-6	MK-7622 is a muscarinic M1 receptor positive allosteric modulator.Target:M1 receptorMK-7622 is useful in the treatment of diseases in which the M1 receptor is involved,such as Alzheimer is disease,schizophreniapain or sleep disorders.	price>
R-R-3055	PHT-7.3 CAS No.1614225-93-2	PHT-7.3/CAS No.1614225-93-2 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.	price>
R-R-3056	SOS1-IN-11 CAS No.2654741-64-5	SOS1-IN-11/CAS No.2654741-64-5 is a potent SOS1 inhibitor with an IC50 value of 30 nM.	price>
R-R-3057	CMC2.24 CAS No.1255639-43-0	CMC2.24 (TRB-N0224)/CAS No.1255639-43-0, an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.	price>
R-R-3058	Kras4B G12D-IN-1 CAS No.2042365-85-3	Kras4B G12D-IN-1/CAS No.2042365-85-3 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566).	price>
R-R-3059	Ketoconazole-d4 CAS No.1398065-75-2	Ketoconazole-d4/CAS No.1398065-75-2 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>
R-R-3060	Atrovastatin-PEG3-FITC CAS No.1440755-31-6	Atrovastatin-PEG3-FITC (compound S31)/CAS No.1440755-31-6 is a KRAS-PDEδ interaction inhibitor. Atrovastatin-PEG3-FITC acts as a ligand in fluorescence anisotropy assay.	price>
R-R-3061	Ketoconazole-d8 CAS No.1217706-96-1	Ketoconazole-d8/CAS No.1217706-96-1 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>

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