Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3055	PHT-7.3 CAS No.1614225-93-2	PHT-7.3/CAS No.1614225-93-2 is a selective inhibitor of connector enhancer of kinase suppressor of Ras 1 (Cnk1) pleckstrin homology (PH) domain (Kd=4.7 μM). PHT-7.3 inhibits mut-KRas, but not wild-type KRas cancer cell and tumor growth and signaling. PHT-7.3 has antitumor activity.	price>
R-R-3056	SOS1-IN-11 CAS No.2654741-64-5	SOS1-IN-11/CAS No.2654741-64-5 is a potent SOS1 inhibitor with an IC50 value of 30 nM.	price>
R-R-3057	CMC2.24 CAS No.1255639-43-0	CMC2.24 (TRB-N0224)/CAS No.1255639-43-0, an orally active tricarbonylmethane agent, is effective against pancreatic tumor in mice by inhibiting Ras activation and its downstream effector ERK1/2 pathway. CMC2.24 is also a potent inhibitor of zinc-dependent MMPs with IC50s ranging from 2.0-69 μM. CMC2.24 alleviates osteoarthritis progression by restoring cartilage homeostasis and inhibiting chondrocyte apoptosis via the NF-κB/HIF-2α axis.	price>
R-R-3058	Kras4B G12D-IN-1 CAS No.2042365-85-3	Kras4B G12D-IN-1/CAS No.2042365-85-3 is a Kras4B G12D inhibitor with anticancer effects. Kras4B G12D-IN-1 decreases Kras protein expression in mouse embryonic fibroblasts (MEF) expressing Kras4B G12D (WO2016179558A1, Comp 994566).	price>
R-R-3059	Ketoconazole-d4 CAS No.1398065-75-2	Ketoconazole-d4/CAS No.1398065-75-2 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>
R-R-3060	Atrovastatin-PEG3-FITC CAS No.1440755-31-6	Atrovastatin-PEG3-FITC (compound S31)/CAS No.1440755-31-6 is a KRAS-PDEδ interaction inhibitor. Atrovastatin-PEG3-FITC acts as a ligand in fluorescence anisotropy assay.	price>
R-R-3061	Ketoconazole-d8 CAS No.1217706-96-1	Ketoconazole-d8/CAS No.1217706-96-1 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.	price>
R-R-3062	Atranorin CAS No.479-20-9	Atranorin/CAS No.479-20-9 is a lichen secondary metabolite. Atranorin inhibits lung cancer cell motility and tumorigenesis by affecting AP-1, Wnt, and STAT signaling and suppressing RhoGTPase activity.	price>
R-R-3063	(S)-JDQ-443 CAS No.2653994-10-4	(S)-JDQ-443/CAS No.2653994-10-4 is an isomer of JDQ-443 (HY-139612). JDQ-443 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). JDQ-443 shows antitumor activity.	price>
R-R-3064	Rac1-IN-3 CAS No.380470-06-4	Rac1-IN-3 (Compound 2)/CAS No.380470-06-4 is a Rac1 inhibitor with an IC50 of 46.1 μM.	price>

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