Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3048	Spiclomazine CAS No.24527-27-3	Spiclomazine (Clospirazine)/CAS No.24527-27-3 is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.	price>
R-R-3049	GDC-6036-NH CAS No.2417918-80-8	GDC-6036-NH/CAS No.2417918-80-8 is from patent WO2020097537A2, and a precursor of compound 17 a/b. Compound 17 a/b is a RAS inhibitor and can be used in cancer research.	price>
R-C-1350	BIBS39 CAS:133085-33-3	BIBS 39 is a new nonpeptide angiotensin II(AII)receptor antagonist.Target: Angiotensin Receptorin vitro: BIBS 39 displaces[125I]AII from its specific binding sites with a Ki value of 29±7 nM for the AII subtype 1(AT1)receptor and a Ki value of 480±110 nM for the AII subtype 2(AT2)receptor.BIBS 222 shows a Ki value of 20±7 nM for the AT1 subtype and a Ki value of 730±170 nM for the AT2 subtype.BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times.	price>
R-R-3050	K-Ras G12C-IN-1 CAS No.1629265-17-3	K-Ras G12C-IN-1/CAS No.1629265-17-3 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.	price>
R-R-3051	KRASG12D-IN-1	KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.	price>
R-R-3052	KRAS G12C inhibitor 28 CAS No.2649004-88-4	KRAS G12C inhibitor 28/CAS No.2649004-88-4 is a KRAS G12C inhibitor with an IC50 of 57 nM. KRAS G12C inhibitor 28 has antitumor effects (WO2021113595A1; Example 1).	price>
R-R-3053	(R)-CE3F4 CAS No.1593478-56-8	(R)-CE3F4/CAS No.1593478-56-8 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.	price>
R-C-1354	Losartan Carboxylic Acid (EXP-3174) CAS:124750-92-1	Losartan Carboxylic Acid(E-3174),an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1(AT1)antagonist.The Ki values are 0.97,0.57,0.67 nM for rat AT1B/AT1A and human AT1,respectively.Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells(VSMC).Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure.	price>
R-R-3054	KRAS G12D inhibitor 1 CAS No.2621928-43-4	KRAS G12D inhibitor 1 (example 243)/CAS No.2621928-43-4 is a KRAS G12D inhibitor, with an IC50 of 0.8 nM for KRAS G12D-mediated ERK phosphorylation. KRAS G12D inhibitor 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-C-1355	MK7622 CAS:1227923-29-6	MK-7622 is a muscarinic M1 receptor positive allosteric modulator.Target:M1 receptorMK-7622 is useful in the treatment of diseases in which the M1 receptor is involved,such as Alzheimer is disease,schizophreniapain or sleep disorders.	price>

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