Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3045	AZD4747 CAS No.2489226-14-2	AZD4747/CAS No.2489226-14-2 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.	price>
R-R-3046	K-Ras G12C-IN-3 CAS No.1629268-19-4	K-Ras G12C-IN-3/CAS No.1629268-19-4 is a novel and irreversible inhibitor of mutant K-ras G12C.	price>
R-R-3047	PROTAC KRAS G12C degrader-2 CAS No.2378257-72-6	PROTAC KRAS G12C degrader-2 (compound 432)/CAS No.2378257-72-6 is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.	price>
R-R-3048	Spiclomazine CAS No.24527-27-3	Spiclomazine (Clospirazine)/CAS No.24527-27-3 is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.	price>
R-R-3049	GDC-6036-NH CAS No.2417918-80-8	GDC-6036-NH/CAS No.2417918-80-8 is from patent WO2020097537A2, and a precursor of compound 17 a/b. Compound 17 a/b is a RAS inhibitor and can be used in cancer research.	price>
R-C-1350	BIBS39 CAS:133085-33-3	BIBS 39 is a new nonpeptide angiotensin II(AII)receptor antagonist.Target: Angiotensin Receptorin vitro: BIBS 39 displaces[125I]AII from its specific binding sites with a Ki value of 29±7 nM for the AII subtype 1(AT1)receptor and a Ki value of 480±110 nM for the AII subtype 2(AT2)receptor.BIBS 222 shows a Ki value of 20±7 nM for the AT1 subtype and a Ki value of 730±170 nM for the AT2 subtype.BIBS 39 is 17 times more selective for the AT1 subtype and BIBS 222 37 times.	price>
R-R-3050	K-Ras G12C-IN-1 CAS No.1629265-17-3	K-Ras G12C-IN-1/CAS No.1629265-17-3 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.	price>
R-R-3051	KRASG12D-IN-1	KRASG12D-IN-1 (compound 22) is a KRASG12D Inhibitor. KRASG12D-IN-1 has dose-dependent anti-tumor efficacy in the AsPC-1 xenograft mouse models with a tumor growth inhibition.	price>
R-R-3052	KRAS G12C inhibitor 28 CAS No.2649004-88-4	KRAS G12C inhibitor 28/CAS No.2649004-88-4 is a KRAS G12C inhibitor with an IC50 of 57 nM. KRAS G12C inhibitor 28 has antitumor effects (WO2021113595A1; Example 1).	price>
R-R-3053	(R)-CE3F4 CAS No.1593478-56-8	(R)-CE3F4/CAS No.1593478-56-8 is a potent and selective inhibitor of exchange protein directly activated by cAMP isoform 1 (Epac1), with an IC50 of 4.2 μM, with 10-fold selectivity for Epac1 over Epac2 (IC50, 44 μM). (R)-CE3F4 is more potent than racemic CE3F4 and (S)-CE3F4.	price>

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