Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3036	Nexinhib20 CAS No.331949-35-0	Nexinhib20/CAS No.331949-35-0 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity.	price>
R-R-3037	ARS-1630 CAS No.1698055-86-5	ARS-1630/CAS No.1698055-86-5, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.	price>
R-C-1338	BMS833923 CAS：1059734-66-5	BMS-833923(XL-139)is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activityinhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.	price>
R-R-3038	KRAS inhibitor-10 CAS No.2578876-75-0	KRAS inhibitor-10 (compound 11)/CAS No.2578876-75-0 selectively and effectively inhibit RAS proteins, and particularly KRAS proteins. KRAS inhibitor-10 is an orally active anti-cancer agent and can be used for cancer research, such as pancreatic cancer, breast cancer, multiple myeloma, leukemia and lung cancer. KRAS inhibitor-10 is a tetrahydroisoquinoline compound (compound 11) extracted from patent WO2021005165 A1.	price>
R-R-3039	KRAS G12C inhibitor 15 CAS No.2349393-21-9	KRAS G12C inhibitor 15/CAS No.2349393-21-9 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.	price>
R-R-3040	APS6-45 CAS No.2188236-41-9	APS6-45/CAS No.2188236-41-9 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity.	price>
R-R-3041	MRTF/SRF-IN-1 CAS No.1922098-90-5	MRTF/SRF-IN-1 (example 41)/CAS No.1922098-90-5 is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis.	price>
R-R-3042	SOS1 activator 1 CAS No.2245237-53-8	SOS1 activator 1 (Compound 64)/CAS No.2245237-53-8 is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS.	price>
R-R-3043	Oncrasin-1 CAS No.75629-57-1	Oncrasin-1/CAS No.75629-57-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.	price>
R-R-3044	PROTAC SOS1 degrader-1 TFA	PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity.	price>

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