Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3039	KRAS G12C inhibitor 15 CAS No.2349393-21-9	KRAS G12C inhibitor 15/CAS No.2349393-21-9 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 22, has an IC50 of 5 nM.	price>
R-R-3040	APS6-45 CAS No.2188236-41-9	APS6-45/CAS No.2188236-41-9 is an orally active tumor-calibrated inhibitor (TCI). APS6-45 inhibits RAS/MAPK signaling and exhibits antitumor activity.	price>
R-R-3041	MRTF/SRF-IN-1 CAS No.1922098-90-5	MRTF/SRF-IN-1 (example 41)/CAS No.1922098-90-5 is an inhibitor of both myocardin-related transcription factor and serum response factor (MRTF/SRF). MRTF/SRF-IN-1 can be used for research for preventing cancer and fibrosis.	price>
R-R-3042	SOS1 activator 1 CAS No.2245237-53-8	SOS1 activator 1 (Compound 64)/CAS No.2245237-53-8 is a potent activator of SOS1-mediated nucleotide exchange with a Kd of 44 nM. SOS1 is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS.	price>
R-R-3043	Oncrasin-1 CAS No.75629-57-1	Oncrasin-1/CAS No.75629-57-1 is a potent and effective anticancer inhibitor that kills various human lung cancer cells with K-Ras mutations at low or submicromolar concentrations; also led to abnormal aggregation of PKCι in nucleus of sensitive cells but not in resistant cells.	price>
R-R-3044	PROTAC SOS1 degrader-1 TFA	PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity.	price>
R-R-3045	AZD4747 CAS No.2489226-14-2	AZD4747/CAS No.2489226-14-2 is a selective, blood-brain barrier-permeable mutant GTPase KRASG12C inhibitor. AZD4747 has the potential to study cancer.	price>
R-R-3046	K-Ras G12C-IN-3 CAS No.1629268-19-4	K-Ras G12C-IN-3/CAS No.1629268-19-4 is a novel and irreversible inhibitor of mutant K-ras G12C.	price>
R-R-3047	PROTAC KRAS G12C degrader-2 CAS No.2378257-72-6	PROTAC KRAS G12C degrader-2 (compound 432)/CAS No.2378257-72-6 is a modulator of K-Ras protein hydrolysis. PROTAC KRAS G12C degrader-2 is a bifunctional compound, which contain on one end a cereblon inhibitor of apoptosis proteins (IAP) and on the other end a moiety which binds KRAS.	price>
R-R-3048	Spiclomazine CAS No.24527-27-3	Spiclomazine (Clospirazine)/CAS No.24527-27-3 is a potent mutant KRAS(G12C) inhibitor that selectively inhibits mutant KRAS-driven pancreatic cancer. Spiclomazine can eliminate KRas-GTP levels in KRAS-driven pancreatic cancer and effectively inhibit RAS-mediated signaling. Spiclomazine significantly inhibits tumor progression in mouse renal capsule xenotransplantation models.	price>

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