Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3031	SOS1-IN-14 CAS No.2793405-20-4	SOS1-IN-14/CAS No.2793405-20-4 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817).	price>
R-R-3032	K-Ras G12C-IN-4 CAS No.2376328-55-9	K-Ras G12C-IN-4/CAS No.2376328-55-9, compound 1, is a potent Covalent Inhibitor of KRASG12C.	price>
R-C-1333	NIBR189 CAS:1599432-08-2	NIBR-189 is a potent and selective EBI2(GPR183)receptor antagonist(IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively).NIBR-189 blocks migration of a monocyte cell line called U937,suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.	price>
R-R-3033	KRAS G12C inhibitor 14 CAS No.2349393-95-7	KRAS G12C inhibitor 14/CAS No.2349393-95-7 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.	price>
R-C-1334	MSX122 CAS：897657-95-3	MSX-122 is an orally bioavailable inhibitor of CXCR4(IC50=10 nM)with potential antineoplastic and antiviral activities.CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4,preventing the binding of stromal derived factor-1 (SDF-1)to the CXCR4 receptor and receptor activation,which may result in decreased tumor cell proliferation and migration.	price>
R-R-3034	RMC-4998 CAS No.2642037-07-6	RMC-4998/CAS No.2642037-07-6 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation.	price>
R-R-3035	6H05 TFA CAS No.2061344-88-3	6H05 TFA/CAS No.2061344-88-3 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).	price>
R-R-3036	Nexinhib20 CAS No.331949-35-0	Nexinhib20/CAS No.331949-35-0 is a specific Rab27a-JFC1 interaction inhibitor with a calculated IC50 of 2.6 μM. Nexinhib20 significantly inhibits superoxide anion production. Nexinhib20 efficiently decreases exocytosis of azurophilic granules in neutrophils stimulated with fMLP, GM-CSF or both. Nexinhib20 has a significant anti-inflammatory activity.	price>
R-R-3037	ARS-1630 CAS No.1698055-86-5	ARS-1630/CAS No.1698055-86-5, a less active enantiomer of ARS-1620, is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1.	price>
R-C-1338	BMS833923 CAS：1059734-66-5	BMS-833923(XL-139)is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activityinhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.	price>

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