Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3028	BI-0474 CAS No.2750570-55-7	BI-0474/CAS No.2750570-55-7 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.	price>
R-R-3029	Rac1 Inhibitor W56 TFA	Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.	price>
R-R-3030	Kobe2602 CAS No.454453-49-7	Kobe2602/CAS No.454453-49-7 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity.	price>
R-R-3031	SOS1-IN-14 CAS No.2793405-20-4	SOS1-IN-14/CAS No.2793405-20-4 is a potent, selective and orally active SOS1 inhibitor with an IC50 value of 3.9 nM. SOS1-IN-14 can be absorbed in the intestine via a P-glycoprotein-mediated efflux mechanism. SOS1-IN-14 can be used to research KRAS-mutated cancers. SOS1-IN-14 has better potent tumor suppression than BI-3406 (HY-125817).	price>
R-R-3032	K-Ras G12C-IN-4 CAS No.2376328-55-9	K-Ras G12C-IN-4/CAS No.2376328-55-9, compound 1, is a potent Covalent Inhibitor of KRASG12C.	price>
R-C-1333	NIBR189 CAS:1599432-08-2	NIBR-189 is a potent and selective EBI2(GPR183)receptor antagonist(IC50 values are 11 and 15 nM for human and mouse EBI2 receptors respectively).NIBR-189 blocks migration of a monocyte cell line called U937,suggesting a functional role of the oxysterol/EBI2 pathway in these immune cells.	price>
R-R-3033	KRAS G12C inhibitor 14 CAS No.2349393-95-7	KRAS G12C inhibitor 14/CAS No.2349393-95-7 is a potent KRAS G12C inhibitor extracted from patent WO2019110751A1, compound 17, has an IC50 of 18 nM.	price>
R-C-1334	MSX122 CAS：897657-95-3	MSX-122 is an orally bioavailable inhibitor of CXCR4(IC50=10 nM)with potential antineoplastic and antiviral activities.CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4,preventing the binding of stromal derived factor-1 (SDF-1)to the CXCR4 receptor and receptor activation,which may result in decreased tumor cell proliferation and migration.	price>
R-R-3034	RMC-4998 CAS No.2642037-07-6	RMC-4998/CAS No.2642037-07-6 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation.	price>
R-R-3035	6H05 TFA CAS No.2061344-88-3	6H05 TFA/CAS No.2061344-88-3 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C).	price>

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