Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3021	AZD4625	AZD4625 (Compound 21) is a highly potent, selective, covalent and allosteric inhibitor of the mutant GTPase KRASG12C. AZD4625 has high oral bioavailability.	price>
R-R-3022	Z62954982 CAS No.1090893-12-1	Z62954982 (ZINC08010136)/CAS No.1090893-12-1 is a potent, selective and cell-permeable Rac1 (IC50=12 μM) inhibitor that is 4 times more effective than NSC23766 (HY-15723A) (IC50=50 μM). Z62954982 disrupts the Rac1/Tiam1 complex and decreases cytoplasmic levels of active Rac1 (GTP-bound Rac1), without affecting the activity of other Rho GTPases (such as Cdc42 or RhoA).	price>
R-R-3023	Antineoplaston A10 CAS No.91531-30-5	Antineoplaston A10/CAS No.91531-30-5, a naturally occurring substance in human body, is a Ras inhibitor potentially for the treatment of glioma, lymphoma, astrocytoma and breast cancer.	price>
R-R-3024	KRpep-2d CAS No.2098181-84-9	KRpep-2d/CAS No.2098181-84-9 is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research.	price>
R-R-3025	MLS000532223 CAS No.16616-39-0	MLS000532223/CAS No.16616-39-0 is a high affinity, selective inhibitor of Rho family GTPases, with EC50 values ranging from 16 μM to 120 μM. MLS000532223 prevents GTP binding to several GTPases.	price>
R-R-3026	RAS/RAS-RAF-IN-1 CAS No.2447039-81-6	RAS/RAS-RAF-IN-1/CAS No.2447039-81-6 is a potent RAS and RAS-RAF inhibitor. RAS/RAS-RAF-IN-1 has a KD of 5.0 μΜ-15 μΜ for cyclophilin A (CYPA) binding affinity. RAS/RAS-RAF-IN-1 has antitumor activity.	price>
R-R-3027	SOS1-IN-15 CAS No.2793404-47-2	SOS1-IN-15 (Compound 37)/CAS No.2793404-47-2 is an orally active SOS1 inhibitor with an IC50 of 5 nM. SOS1-IN-15 is a promising agent candidate for the research of KRAS-driven cancer.	price>
R-R-3028	BI-0474 CAS No.2750570-55-7	BI-0474/CAS No.2750570-55-7 is a potent KRASG12C inhibitor with an IC50 value of 7.0 nM for the GDP-KRAS::SOS1 protein-protein interaction. BI-0474 exhibits good anti-proliferative activity against NCI-H358 cells carrying the G12C mutation. BI-0474 also shows good anti-tumour activity in non-small cell lung cancer xenograft models.	price>
R-R-3029	Rac1 Inhibitor W56 TFA	Rac1 Inhibitor W56 TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor W56 TFA inhibits Rac1 interaction with guanine nucleotide exchange factors TrioN, GEF-H1, and Tiam.	price>
R-R-3030	Kobe2602 CAS No.454453-49-7	Kobe2602/CAS No.454453-49-7 is a Ras-Raf interaction inhibitor. Kobe2602 inhibits the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki of 149 μM. Kobe2602 has antitumor activity.	price>

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