Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3001	HJC0197 CAS No.1383539-73-8	HJC0197/CAS No.1383539-73-8 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.	price>
R-R-3002	CCG-100602 CAS No.1207113-88-9	CCG-100602/CAS No.1207113-88-9 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF.	price>
R-R-3003	ML-097 CAS No.743456-83-9	ML-097 (CID-2160985)/CAS No.743456-83-9 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7.	price>
R-R-3004	KRA-533 CAS No.10161-87-2	KRA-533/CAS No.10161-87-2 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.	price>
R-R-3005	RBC8 CAS No.361185-42-4	RBC8/CAS No.361185-42-4 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.	price>
R-R-3007	KRAS G12C inhibitor 19 CAS No.2649788-46-3	KRAS G12C inhibitor 19/CAS No.2649788-46-3 is a potent inhibitor of KRAS G12C. KRAS G12C inhibitor 19 significantly inhibits tumor growth (extracted from patent WO2021118877A1).	price>
R-R-3008	MRTX-EX185 formic	MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS. MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-3009	KRAS inhibitor-3 CAS No.900897-56-5	KRAS inhibitor-3/CAS No.900897-56-5 is an inhibitor of KRAS inhibitor. KRAS inhibitor-3 binds to WT and oncogenic KRAS mutants with high affinity (KD: 0.28 μM for KRAS WT, 0.63 μM for KRAS G12C, 0.37 μM for KRAS G12D, 0.74 μM for KRAS Q61H). KRAS inhibitor-3 also disrupts interaction of KRAS with Raf.	price>
R-R-3010	CID44216842 CAS No.1222513-26-9	CID44216842 (Cdc42-IN-1)/CAS No.1222513-26-9 is a potent Cdc42-selective guanine nucleotide binding lead inhibitor. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 1.0 and 1.2 μM in GTP binding assay, respectively. The EC50s for Cdc42 WT and Cdc42Q61L mutant are 0.3 and 0.5 μM in GDP binding assay, respectively. Use as a molecular probe.	price>
R-R-3011	MCP110 CAS No.521310-51-0	MCP110/CAS No.521310-51-0 is an inhibitor of Ras/Raf-1 interaction. MCP110 blocks the interaction of Ras with Raf. MCP110 disrupts this interaction might can be used for the research of human tumors.	price>

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