Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2998	MLS-573151 CAS No.10179-57-4	MLS-573151 (MLS000573151)/CAS No.10179-57-4 is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42.	price>
R-R-2999	AZA1 CAS No.1071098-42-4	AZA1/CAS No.1071098-42-4 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.	price>
R-R-3000	GGTI298 CAS No.180977-44-0	GGTI298/CAS No.180977-44-0 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.	price>
R-R-3001	HJC0197 CAS No.1383539-73-8	HJC0197/CAS No.1383539-73-8 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.	price>
R-R-3002	CCG-100602 CAS No.1207113-88-9	CCG-100602/CAS No.1207113-88-9 is a specific inhibitor of myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) signaling. CCG-100602 specifically block MRTF-A nuclear localization and thus inhibit the fibrogenic transcription factor SRF.	price>
R-R-3003	ML-097 CAS No.743456-83-9	ML-097 (CID-2160985)/CAS No.743456-83-9 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, and Rab7.	price>
R-R-3004	KRA-533 CAS No.10161-87-2	KRA-533/CAS No.10161-87-2 is a potent KRAS agonist. KRA-533 binds to the GTP/GDP binding pocket in the KRAS protein to prevent GTP cleavage, resulting in the accumulation of constitutively active GTP-bound KRAS that triggers both apoptotic and autophagic cell death pathways in cancer cells.	price>
R-R-3005	RBC8 CAS No.361185-42-4	RBC8/CAS No.361185-42-4 is a novel small molecule inhibitor of Ral GTPase; has IC50 of 3.	price>
R-R-3007	KRAS G12C inhibitor 19 CAS No.2649788-46-3	KRAS G12C inhibitor 19/CAS No.2649788-46-3 is a potent inhibitor of KRAS G12C. KRAS G12C inhibitor 19 significantly inhibits tumor growth (extracted from patent WO2021118877A1).	price>
R-R-3008	MRTX-EX185 formic	MRTX-EX185 formic is a potent inhibitor of GDP-loaded KRAS and KRAS(G12D), with an IC50 of 90 nM for KRAS(G12D). MRTX-EX185 formic also binds GDP-loaded HRAS. MRTX-EX185 (formic) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>

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