Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2992	Rasarfin CAS No.674359-73-0	Rasarfin/CAS No.674359-73-0 is a dual Ras and ARF6 inhibitor.	price>
R-R-2993	CE3F4 CAS No.143703-25-7	CE3F4/CAS No.143703-25-7 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.	price>
R-R-2994	RMC-0331 CAS No.2488788-52-7	RMC-0331 (RM-023)/CAS No.2488788-52-7 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.	price>
R-R-2995	RAS inhibitor Abd-7 CAS No.2351843-48-4	RAS inhibitor Abd-7/CAS No.2351843-48-4, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.	price>
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>
R-R-2997	8-CPT-2Me-cAMP sodium CAS No.634207-53-7	8-CPT-2Me-cAMP sodium/CAS No.634207-53-7 is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.	price>
R-R-2998	MLS-573151 CAS No.10179-57-4	MLS-573151 (MLS000573151)/CAS No.10179-57-4 is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42.	price>
R-R-2999	AZA1 CAS No.1071098-42-4	AZA1/CAS No.1071098-42-4 is a potent dual inhibitor of Rac1 and Cdc42. AZA1 induces prostate cancer cells apoptosis and inhibits prostate cancer cells proliferation, migration and invasion.	price>
R-R-3000	GGTI298 CAS No.180977-44-0	GGTI298/CAS No.180977-44-0 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, with IC50 values of 3 and > 20 μM in vivo, respectively.	price>
R-R-3001	HJC0197 CAS No.1383539-73-8	HJC0197/CAS No.1383539-73-8 is a potent Epac1 (exchange protein directly activated by cAMP 1) and Epac2 (IC50=5.9 μM for Epac2) antagonist. HJC0197 selectively blocks cAMP-induced Epac activation. HJC0197 inhibits Epac1-mediated Rap1-GDP exchange activity at 25 μM in the presence of equal concentration of cAMP.	price>

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