Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2988	Digeranyl bisphosphonate CAS No.878143-03-4	Digeranyl bisphosphonate (DGBP)/CAS No.878143-03-4 is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.	price>
R-R-2989	Pan KRas-IN-1 CAS No.2791263-84-6	Pan KRas-IN-1/CAS No.2791263-84-6 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.	price>
R-R-2990	BQU57 CAS No.1637739-82-2	BQU57/CAS No.1637739-82-2 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.	price>
R-R-2991	CCG-203971 CAS No.1443437-74-8	CCG-203971/CAS No.1443437-74-8 is a second-generation Rho/MRTF/SRF pathway inhibitor. CCG-203971 potently targets RhoA/C-activated SRE-luciferase (IC50 =6.4 μM). CCG-203971 inhibits PC-3 cell migration with an IC50 of 4.2 μM. Potential anti-metastasis Agent.	price>
R-R-2992	Rasarfin CAS No.674359-73-0	Rasarfin/CAS No.674359-73-0 is a dual Ras and ARF6 inhibitor.	price>
R-R-2993	CE3F4 CAS No.143703-25-7	CE3F4/CAS No.143703-25-7 is a selective antagonist of exchange protein directly activated by cAMP (Epac1), with IC50s of 10.7 μM and 66 μM for Epac1 and Epac2(B), respectively.	price>
R-R-2994	RMC-0331 CAS No.2488788-52-7	RMC-0331 (RM-023)/CAS No.2488788-52-7 is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction.	price>
R-R-2995	RAS inhibitor Abd-7 CAS No.2351843-48-4	RAS inhibitor Abd-7/CAS No.2351843-48-4, a potent RAS-binding compound (Kd=51 nM), is a RAS-effector protein-protein interaction (PPI) inhibitor. RAS inhibitor Abd-7 interacts with RAS inside the cells, prevents RAS-effector interactions and inhibits endogenous RAS-dependent signaling. RAS inhibitor Abd-7 impairs the PPI of various mutant KRAS proteins with PI3K, CRAF and RALGDS as well as NRAS Q61H and HRAS G12V.	price>
R-R-2996	RM-018 CAS No.2641993-55-5	RM-018/CAS No.2641993-55-5 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS(ON)”] state of KRASG12C.	price>
R-R-2997	8-CPT-2Me-cAMP sodium CAS No.634207-53-7	8-CPT-2Me-cAMP sodium/CAS No.634207-53-7 is a selective activator of exchange proteins activated by cAMP (Epac), the cAMP sensitive guanine nucleotide exchange factors (GEFs) for the small GTPases Rap1 and Rap2. 8-CPT-2Me-cAMP sodium activates Epac1 (EC50 = 2.2 μM), but not PKA (EC50> 10 μM). 8-CPT-2Me-cAMP sodium stimulates Epac-mediated Ca2+ release in pancreatic β-cells in vitro.	price>

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