Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2972	MRTX0902 CAS No.2654743-22-1	MRTX0902/CAS No.2654743-22-1 is an orally active and potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10).	price>
R-R-2973	Opnurasib CAS No.2653994-08-0	Opnurasib (JDQ-443) (NVP-JDQ443)/CAS No.2653994-08-0 is an orally active, potent, selective, and covalent KRAS G12C inhibitor (extracted from patent WO2021120890A1). Opnurasib shows antitumor activity.	price>
R-R-2974	LC-2 CAS No.2502156-03-6	LC-2/CAS No.2502156-03-6 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.	price>
R-C-1275	JNJ 31020028 CAS No. 1094873-14-9	JNJ-31020028 is a selective brain penetrant antagonist of neuropeptide Y2 receptor with high affinity(pIC50=8.07,human;pIC50=8.22 rat);>100-fold selective versus human Y1/Y4/Y5 receptors.	price>
R-R-2975	RMC-6291 CAS No.2641998-63-0	RMC-6291/CAS No.2641998-63-0 is an orally active and covalent inhibitor of KRASG12C(ON). RMC-6291 forms a tri-complex within tumor cells between KRASG12C(ON) and cyclophilin A (CypA). Thus, RMC-6291 prevents KRASG12C(ON) from signaling via steric blockade of RAS effector binding. RMC-6291 inhibits ERK signaling and induced apoptosis in KRASG12C-mutant H358 cells. RMC-6291 also inhibits the proliferation of KRASG12C mutant cells with a median IC50 of 0.11 nM.	price>
R-R-2976	CASIN CAS No.425399-05-9	CASIN/CAS No.425399-05-9 is a selective GTPase Cdc42 inhibitor with an IC50 of 2 uM. CASIN can be used for the research of cancer.	price>
R-R-2977	Salirasib CAS No.162520-00-5	Salirasib/CAS No.162520-00-5 is a Ras inhibitor that inhibits specifically both oncogenically activated Ras and growth factor receptor-mediated Ras activation, resulting in the inhibition of Ras-dependent tumor growth.	price>
R-R-2978	ML-098 CAS No.878978-76-8	ML-098 (CID-7345532)/CAS No.878978-76-8 is an activator of the GTP-binding protein Rab7 with an EC50 of 77.6 nM.	price>
R-R-2979	RAS-IN-2 CAS No.2765081-21-6	RAS-IN-2 (Compound A122)/CAS No.2765081-21-6 is a potent RAS(ON)MULTI inhibitor and can be used for the research of cancer.	price>
R-R-2980	MRTX-1257 CAS No.2206736-04-9	MRTX-1257/CAS No.2206736-04-9 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells.	price>

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