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LC-2 CAS No.2502156-03-6
LC-2 CAS No.2502156-03-6
| Catalog # | Pkg Size | Price(USD) | Quantity | Buy this product |
|---|---|---|---|---|
| R-R-2974 | 1mg | 310.00 | + Add to cart |
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| R-R-2974 | 2mg | 520.00 | + Add to cart |
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Product description
LC-2/CAS No.2502156-03-6 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines.
| Appearance | N/A |
|---|---|
| Molecular Weight | 1133.00 |
| Purity | >90% |
| CAS | 2502156-03-6 |
| Formula | C59H71ClFN11O7S |
| Storage | -20℃, protected from light and moisture |
| Transportation | 4-25℃ temperature for up to 2 weeks |
| Stability | 1 year |
Document
msds of LC-2 CAS No.2502156-03-6 Related Product
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