Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2960	BI-2865 CAS No.2937327-93-8	BI-2865/CAS No.2937327-93-8 is a none-covalent pan-KRAS Inhibitor. BI-2865 binds to WT, G12C, G12D, G12V and G13D mutant KRAS with KDs of 6.9, 4.5, 32, 26, 4.3 nM respectively. BI-2865 inhibits the proliferation of G12C, G12D or G12V mutant KRAS expressing BaF3 cells (mean IC50: roughly 140 nM).	price>
R-R-2961	BI-2852 CAS No.2375482-51-0	BI-2852/CAS No.2375482-51-0 is a KRAS inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based agent design with nanomolar affinity. BI-2852 is mechanistically distinct from covalent KRASG12C inhibitor (binds to switch II pocket) and binds ten-fold more strongly to active KRASG12D versus KRASwt (740 nM vs 7.5 μM). BI-2852 blocks GEF, GAP, and effector interactions with KRAS, leading to inhibition of downstream signaling and an antiproliferative effect in KRAS mutant cells.	price>
R-R-2962	BI-2493 CAS No.2937344-16-4	BI-2493/CAS No.2937344-16-4 is a structural analogue of BI-2865 and a highly selective pan-KRAS inhibitor. BI-2493 can attenuate tumor growth. BI-2493 can be used for cancer iseases research.	price>
R-C-1263	AM251 CAS：183232-66-8	AM251 is a potent CB1 receptor antagonist(IC50=8 nM,Ki=7.49 nM)that displays 306-fold selectivity over CB2 receptors.	price>
R-R-2963	LUNA18 CAS No.2676177-63-0	LUNA18/CAS No.2676177-63-0 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer.	price>
R-R-2964	BI-3406 CAS No.2230836-55-0	BI-3406 (compound I-6)/CAS No.2230836-55-0 is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity.	price>
R-R-2965	NSC 23766 trihydrochloride CAS No.1177865-17-6	NSC 23766 trihydrochloride/CAS No.1177865-17-6 is an inhibitor of Rac1 activation.	price>
R-R-2966	CID-1067700 CAS No.314042-01-8	CID-1067700 (ML282)/CAS No.314042-01-8 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.	price>
R-R-2967	Lonafarnib CAS No.193275-84-2	Lonafarnib (Sch66336)/CAS No.193275-84-2 is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.	price>
R-R-2968	Divarasib CAS No.2417987-45-0	Divarasib (GDC-6036)/CAS No.2417987-45-0 is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.	price>

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