Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2963	LUNA18 CAS No.2676177-63-0	LUNA18/CAS No.2676177-63-0 is an orally active KRAS inhibitor with an IC50 of ＜2 nM against KRASG12D-SOS. LUNA18 can be used for the research of cancer.	price>
R-R-2964	BI-3406 CAS No.2230836-55-0	BI-3406 (compound I-6)/CAS No.2230836-55-0 is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity.	price>
R-R-2965	NSC 23766 trihydrochloride CAS No.1177865-17-6	NSC 23766 trihydrochloride/CAS No.1177865-17-6 is an inhibitor of Rac1 activation.	price>
R-R-2966	CID-1067700 CAS No.314042-01-8	CID-1067700 (ML282)/CAS No.314042-01-8 is a pan GTPase inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.	price>
R-R-2967	Lonafarnib CAS No.193275-84-2	Lonafarnib (Sch66336)/CAS No.193275-84-2 is a potent and orally active farnesyl transferase (FTase) inhibitor. Lonafarnib inhibits the activities of H-ras, K-ras and N-ras with IC50 values of 1.9 nM, 5.2 nM and 2.8 nM, respectively. Lonafarnib also has anti-hepatitis delta virus (HDV) activities.	price>
R-R-2968	Divarasib CAS No.2417987-45-0	Divarasib (GDC-6036)/CAS No.2417987-45-0 is an orally bioavailable, highly potent, and selective KRAS G12C inhibitor with an IC50 of <0.01 μM. Divarasib covalently binds to the switch II (SW-II) pocket of KRAS G12C and irreversibly locks it in the inactive GDP-bound state.	price>
R-R-2969	BAY-293 CAS No.2244904-70-7	BAY-293/CAS No.2244904-70-7, a valuable chemical probe, blocks RAS activation via disruption of the KRAS-SOS1 interaction with an IC50 of 21 nM. BAY-293 is a potent inhibitor of Son of Sevenless 1 (SOS1). SOS1 is the guanine nucleotide exchange factor (GEF) and activator of RAS.	price>
R-R-2970	GGTI298 Trifluoroacetate CAS No.1217457-86-7	GGTI298 Trifluoroacetate/CAS No.1217457-86-7 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, which can inhibit Rap1A with IC50 of 3 μM; little effect on Ha-Ras with IC50 of >20 μM.	price>
R-R-2971	MBQ-167 CAS No.2097938-73-1	MBQ-167/CAS No.2097938-73-1 is a dual Rac/Cdc42 inhibitor, with IC50s of 103 nM for Rac 1/2/3 and 78 nM for Cdc42 in MDA-MB-231 cells, respectively.	price>
R-R-2972	MRTX0902 CAS No.2654743-22-1	MRTX0902/CAS No.2654743-22-1 is an orally active and potent SOS1 inhibitor with an IC50 of 46 nM (WO2021127429A1; Example 12-10).	price>

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