Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2943	LY83583 CAS No.91300-60-6	LY83583/CAS No.91300-60-6 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM.	price>
R-R-2944	Zagociguat CAS No.2201048-82-8	Zagociguat/CAS No.2201048-82-8 is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders.	price>
R-R-2945	Plecanatide CAS No.467426-54-6	Plecanatide/CAS No.467426-54-6, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis.	price>
R-R-2946	(Rac)-MGV354 CAS No.1852495-86-3	(Rac)-MGV354/CAS No.1852495-86-3 is the racemate of MGV354. MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.	price>
R-R-2947	BAY 41-8543 CAS No.256498-66-5	BAY 41-8543/CAS No.256498-66-5 is an orally active, nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). BAY 41-8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41-8543 has antiplatelet effects and has the potential for cardiovascular diseases research.	price>
R-R-2948	BAY-747 CAS No.1609342-18-8	BAY-747/CAS No.1609342-18-8 is an orally active and brain-penetrant stimulator of soluble guanylate cyclase (sGC). BAY-747 reverses L-NAME induced memory impairments and enhances cognition of rats in the object location task (OLT). BAY-747 also decreases blood pressure in both conscious normotensive and spontaneously hypertensive rats (SHR). BAY-747 improves function of the skeletal muscle associated with Duchenne muscular dystrophy (DMD) in mdx/mTRG2 mice model.	price>
R-R-2949	Nelociguat CAS No.625115-52-8	Nelociguat (BAY60-4552)/CAS No.625115-52-8 is a nitric oxide sensitive soluble guanylate cyclase stimulator.	price>
R-R-2950	Plecanatide acetate CAS No.1075732-84-1	Plecanatide acetate/CAS No.1075732-84-1, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide acetate activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide acetate can be used for the research of chronic idiopathic constipation, and it also shows anti-inflammatory activity in models of murine colitis.	price>
R-R-2951	MM 419447 CAS No.1092457-78-7	MM 419447/CAS No.1092457-78-7, a linaclotide metabolite, is a guanylate cyclase-C agonist. MM 419447 has the potential for the research of the irritable bowel syndrome with constipation (IBS-C).	price>
R-R-2952	CFM 1571 hydrochloride CAS No.1215548-30-3	CFM 1571 hydrochloride/CAS No.1215548-30-3 is the stimulator of the nitric oxide receptor, soluble guanylate cyclase (sGC) with an EC50 and IC50 of 5.49 μM and 2.84 μM, respectively. Soluble guanylate cyclase (sGC) is a key signal-transduction enzyme activated by nitric oxide (NO). CFM 1571 hydrochloride has the potential for the research of cardiovascular and other diseases.	price>

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