Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2933	ODQ CAS No.41443-28-1	ODQ/CAS No.41443-28-1 is a potent and selective soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) inhibitor. ODQ enhances the pro-apoptotic effects of Cisplatin in human mesothelioma cells.	price>
R-R-2934	BAY 41-2272 CAS No.256376-24-6	BAY 41-2272/CAS No.256376-24-6 is an orally active and soluble guanylate cyclases (sGC) activator, which increases sGC activity by 400-fold in synergy with NO. BAY 41-2272 potently unloaded the heart, increased cardiac output, thus can be used for cardiovascular diseases research.	price>
R-R-2935	BAY 60-2770 CAS No.1027642-43-8	BAY 60-2770/CAS No.1027642-43-8 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.	price>
R-R-2936	Runcaciguat CAS No.1402936-61-1	Runcaciguat/CAS No.1402936-61-1 is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.	price>
R-R-2937	NS-2028 CAS No.204326-43-2	NS-2028/CAS No.204326-43-2 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.	price>
R-R-2938	Ataciguat CAS No.254877-67-3	Ataciguat (HMR-1766)/CAS No.254877-67-3 is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.	price>
R-R-2939	Cinaciguat hydrochloride CAS No.646995-35-9	Cinaciguat hydrochloride/CAS No.646995-35-9 is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.	price>
R-R-2940	Praliciguat CAS No.1628730-49-3	Praliciguat (IW-1973)/CAS No.1628730-49-3 is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.	price>
R-R-2941	Olinciguat CAS No.1628732-62-6	Olinciguat (IW-1701)/CAS No.1628732-62-6 is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.	price>
R-R-2942	Indusatumab CAS No.1497400-26-6	Indusatumab (5F9 Monoclonal antibody)/CAS No.1497400-26-6 is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody.	price>

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