Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2935	BAY 60-2770 CAS No.1027642-43-8	BAY 60-2770/CAS No.1027642-43-8 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator. BAY 60-2770 increases the activity of sGC in a nitric oxide-independent manner. BAY 60-2770 shows antifibrotic effect.	price>
R-R-2936	Runcaciguat CAS No.1402936-61-1	Runcaciguat/CAS No.1402936-61-1 is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.	price>
R-R-2937	NS-2028 CAS No.204326-43-2	NS-2028/CAS No.204326-43-2 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.	price>
R-R-2938	Ataciguat CAS No.254877-67-3	Ataciguat (HMR-1766)/CAS No.254877-67-3 is a nitric oxide-independent soluble guanylate cyclase (sGC) activator. Ataciguat is able to activate the ferric heme-iron redox form of sGC that stimulate the production of cyclic GMP (cGMP). Ataciguat exhibits vasodilator effects.	price>
R-R-2939	Cinaciguat hydrochloride CAS No.646995-35-9	Cinaciguat hydrochloride/CAS No.646995-35-9 is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.	price>
R-R-2940	Praliciguat CAS No.1628730-49-3	Praliciguat (IW-1973)/CAS No.1628730-49-3 is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator. Praliciguat (IW-1973) stimulates sGC in HEK-293 cells with an EC50 of 197 nM.	price>
R-R-2941	Olinciguat CAS No.1628732-62-6	Olinciguat (IW-1701)/CAS No.1628732-62-6 is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.	price>
R-R-2942	Indusatumab CAS No.1497400-26-6	Indusatumab (5F9 Monoclonal antibody)/CAS No.1497400-26-6 is an anti-human GUCY2C (Guanylate cyclase 2C) monoclonal antibody.	price>
R-R-2943	LY83583 CAS No.91300-60-6	LY83583/CAS No.91300-60-6 is a cell-permeable and competitive inhibitor of soluble guanylate cyclase (sGC) with an IC50 value of 2 µM.	price>
R-R-2944	Zagociguat CAS No.2201048-82-8	Zagociguat/CAS No.2201048-82-8 is the stimulator of soluble guanylate cyclase. Zagociguat increases nitric oxide (NO) signaling leading to an increase in cyclic guanosine monophosphate production. Zagociguat has the potential for the research of noncentral nervous system (CNS) disorders.	price>

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