Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2920	CB1R Allosteric modulator 3 CAS No.2633686-36-7	CB1R Allosteric modulator 3/CAS No.2633686-36-7 is a CB1R positive allosteric modulator. CB1R Allosteric modulator 3 has potent inhibition of cAMP and β-Arrestin with EC50 values of 0.018 μM and 1.241 μM, respectively.	price>
R-R-2921	ELA-11(human) CAS No.1784687-32-6	ELA-11(human)/CAS No.1784687-32-6, a peptide, is a full agonist of human apelin receptor, with a pKi of 7.85. ELA-11(human) completely inhibits Forskolin-induced cAMP production and stimulates β-arrestin recruitment.	price>
R-R-2922	GRK6-IN-1 CAS No.2677786-61-5	GRK6-IN-1 (compound 18)/CAS No.2677786-61-5 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-1 has the potential for the research of multiple myeloma.	price>
R-R-2923	GRK5-IN-2 CAS No.1642839-27-7	GRK5-IN-2 (compound 707)/CAS No.1642839-27-7, a pyridine-based bicyclic compound, is a potent G-protein-coupled receptor kinase 5 (GRK5) inhibitor. GRK5-IN-2 regulates the expression and/or release of insulin and is useful for the metabolic disease research.	price>
R-R-2924	CCG258208 hydrochloride	CCG258208 (GRK2-IN-1) hydrochloride is a potent and selective GRK2 (G protein-coupled receptor kinase 2) inhibitor (IC50=30 nM) while maintaining 230-fold selectivity over GRK5 (IC50=7.09 μM) and more than 2500-fold selectivity over GRK1 (IC50=87.3 μM), PKA, and ROCK1. CCG258208 hydrochloride can be used in heart failure research.	price>
R-R-2925	GRK6-IN-2 CAS No.2677786-27-3	GRK6-IN-2 (compound 10a)/CAS No.2677786-27-3 is a potent inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 120 nM. GRK6 is a critical kinase required for the survival of multiple myeloma (MM) cells. GRK6-IN-2 has the potential for the research of multiple myeloma.	price>
R-R-2926	CCG273441 CAS No.2750414-35-6	CCG273441/CAS No.2750414-35-6 is a covalent inhibitor of G protein-coupled receptor (GPCR) kinase 5 (GRK5) with an IC50 value of 3.8 nM. CCG273441 is highly selective to GRK5 over GRK2 (IC50=4.8 μM) by binding Cys474, a GRK5 subfamily-specific residue, as a covalent handle.	price>
R-R-2927	KR-39038 CAS No.2770300-35-9	KR-39038/CAS No.2770300-35-9 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC50 of 0.02 μM. KR-39038 significantly inhibits angiotensin II-induced cellular hypertrophy through suppression of HDAC5 pathway in neonatal cardiomyocytes. KR-39038 shows profound anti-hypertrophic effects and improved cardiac function. KR-39038 can be used for heart failure research.	price>
R-R-2928	GRK2i TFA	GRK2i TFA is a GRK2 inhibitory polypeptide that specifically inhibits Gβγ activation of GRK2. GRK2i TFA corresponds to the Gβγ-binding domain and acts as a cellular Gβγ antagonist.	price>
R-R-2929	Lificiguat CAS No.170632-47-0	Lificiguat/CAS No.170632-47-0 binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.	price>

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