Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2981	FTI-277 hydrochloride CAS No.180977-34-8	FTI-277 hydrochloride/CAS No.180977-34-8 is an inhibitor of farnesyl transferase (FTase); a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.	price>
R-R-2982	Sotorasib racemate CAS No.2252403-56-6	Sotorasib racemate (Compound A)/CAS No.2252403-56-6 is an orally active racemate of Sotorasib (HY-114277), a covalent inhibitor of KRAS G12C mutant which induces adaptive feedback activation of MAPK pathway. Sotorasib racemate also exerts inhibitor activity against KRAS G12C induced cancer and can be applied to cancer research.	price>
R-R-2983	Pan-RAS-IN-1 CAS No.1835283-94-7	Pan-RAS-IN-1/CAS No.1835283-94-7 is a pan-Ras inhibitor that disrupts the interaction of Ras proteins and their effectors.	price>
R-R-2984	BDP9066 CAS No.2226507-04-4	BDP9066/CAS No.2226507-04-4 is a potent and selective myotonic dystrophy-related Cdc42-binding kinase MRCK inhibitor with an IC50 of 64 nM for MRCKβ in SCC12 cells, Ki values of 0.0136 nM and 0.0233 nM for MRCKα/β in house determinations, respectively. BDP9066 has therapeutic effect on skin cancer by reducing substrate phosphorylation.	price>
R-R-2985	CCG-222740 CAS No.1922098-69-8	CCG-222740/CAS No.1922098-69-8 is an orally active and selective Rho/myocardin-related transcription factor (MRTF) pathway inhibitor. CCG-222740 is also a potent inhibitor of alpha-smooth muscle actin protein expression. CCG-222740 effectively reduces fibrosis in skin and blocks melanoma metastasis.	price>
R-R-2986	PROTAC K-Ras Degrader-1 CAS No.2378258-52-5	PROTAC K-Ras Degrader-1 (Compound 518)/CAS No.2378258-52-5 is a PROTAC. PROTAC K-Ras Degrader-1 can effectively degrades K-Ras based on Cereblon E3 ligand, exhibits ≥70% degradation efficacy in SW1573 cells.	price>
R-R-2987	ML-099 CAS No.496775-95-2	ML-099 (CID-888706)/CAS No.496775-95-2 is a pan Ras-related GTPases activator that can activate Rac1, cell division cycle 42, Ras, Rab7, and Rab-2A.	price>
R-R-2988	Digeranyl bisphosphonate CAS No.878143-03-4	Digeranyl bisphosphonate (DGBP)/CAS No.878143-03-4 is a potent geranylgeranylpyrophosphate (GGPP) synthase inhibitor, which inhibits geranylgeranylation of Rac1.	price>
R-R-2989	Pan KRas-IN-1 CAS No.2791263-84-6	Pan KRas-IN-1/CAS No.2791263-84-6 is a pan KRas inhibitor, can be used for agent resistance in cancer developed with KRas G12C inhibitors.	price>
R-R-2990	BQU57 CAS No.1637739-82-2	BQU57/CAS No.1637739-82-2 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358.	price>

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