Product apis-gpcr-g-protein

Home > products > apis> gpcr-g-protein

Catalog	name	Description	price
R-R-2745	VU0364770 hydrochloride CAS No.1414842-70-8	VU0364770 hydrochloride/CAS No.1414842-70-8 is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively.	price>
R-R-2746	mGluR3 modulator-1 CAS No.374548-18-2	mGluR3 modulator-1 (compound 3)/CAS No.374548-18-2 is a mGluR3 modulator, with an EC50 of 1-10 μM in HEK293T-mGluR-Gqi5 Calcium Mobilization Assay.	price>
R-R-2747	AZD 2066 CAS No.934282-55-0	AZD 2066/CAS No.934282-55-0 is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 has antinociception effects.	price>
R-R-2749	AMN082 free base CAS No.83027-13-8	AMN082 free base/CAS No.83027-13-8, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 free base potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 free base shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.	price>
R-R-2750	CPCCOEt CAS No.179067-99-3	CPCCOEt/CAS No.179067-99-3 is a low affinity, selective, non-competitive and reversible antagonist of metabotropic glutamate receptor 1b (mGluR1b).	price>
R-R-2751	AZD 2066 hydrate	AZD 2066 hydrate is a selective, orally active and brain-penetrant antagonist of mGluR5. AZD 2066 hydrate has antinociception effects.	price>
R-R-2752	DFMTI CAS No.864864-86-8	DFMTI/CAS No.864864-86-8 can completely block the rmGlu1 L757V glutamate response.	price>
R-R-2753	Mavoglurant racemate CAS No.1636881-61-2	Mavoglurant racemate (AFQ-056 racemate)/CAS No.1636881-61-2 is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist. Mavoglurant (racemate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2754	VU6010572 CAS No.2126784-39-0	VU6010572/CAS No.2126784-39-0 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant.	price>
R-R-2755	VU0155094 CAS No.731006-86-3	VU0155094/CAS No.731006-86-3 is a positive allosteric modulator with differential activity at the various group III mGluRs.	price>

...

163