Product apis-gpcr-g-protein

Home > products > apis> gpcr-g-protein

Catalog	name	Description	price
R-R-2735	VU0360172 CAS No.1310012-12-4	VU0360172/CAS No.1310012-12-4 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2736	L-AP4 monohydrate CAS No.2247534-79-6	L-AP4 (L-APB) monohydrate/CAS No.2247534-79-6 is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively.	price>
R-R-2737	LY2389575 hydrochloride CAS No.885104-09-6	LY2389575 hydrochloride/CAS No.885104-09-6 is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels.	price>
R-R-2738	VU0080241 CAS No.393845-24-4	VU0080241/CAS No.393845-24-4 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM.	price>
R-R-2739	VU-1545 CAS No.890764-63-3	VU-1545/CAS No.890764-63-3 is a metabotropic glutamate receptor 5 positive allosteric modulator (mGluR5 PAM) with a Ki of 156 nM and an EC50 of 9.6 nM.	price>
R-R-2740	MNI137 CAS No.946619-21-2	MNI137/CAS No.946619-21-2 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization.	price>
R-R-2741	ML254 CAS No.1428630-86-7	ML254/CAS No.1428630-86-7 is a potent mGlu5 potentiator, with EC50 and pEC50 of 9.3 nM and 8.03 nM for rat mGlu5, respectively. ML254 can be used for researching schizophrenia. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2742	DCG-IV CAS No.147782-19-2	DCG-IV/CAS No.147782-19-2 is a potent agonist of group II mGluRs with EC50s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC50: mGlu1R/5R=389/630 μM) and III receptors (IC50: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects.	price>
R-R-2743	L-Cysteinesulfinic acid monohydrate CAS No.207121-48-0	L-Cysteinesulfinic acid monohydrate/CAS No.207121-48-0 is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.	price>
R-R-2744	(RS)-PPG CAS No.120667-15-4	(RS)-PPG/CAS No.120667-15-4 is a potent and selective agonist for group III mGluRs. The EC50s of 5.2 μM, 4.7 μM, 185 μM, and 0.2 μM for hmGluR4a, hmGluR6, hmGluR7b, and hmGluR8a, respectively. Anticonvulsive and neuroprotective activity.	price>

...

163