Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2756	(rel)-Eglumegad CAS No.176027-90-0	(rel)-Eglumegad ((rel)-LY354740)/CAS No.176027-90-0 is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors, respectively.	price>
R-R-2757	rel-ACPT-I CAS No.194918-76-8	rel-ACPT-I/CAS No.194918-76-8 is an agonist of group III mGluRs with diverse biological activities including neuroprotective, anticonvulsant, and anxiolytic-like effects.	price>
R-R-2758	A-841720 CAS No.869802-58-4	A-841720/CAS No.869802-58-4 is a potent, non-competitive and selective mGlu1 receptor antagonist with an IC50 of 10 nM for human mGlu1 receptor. A-841720 displays 34-fold selectivity over mGlu5 (IC50 of 342 nM), and no significant activity at a range of other neurotransmitter receptors, ion channels, and transporters. A-841720 has the potential for chronic pain research.	price>
R-R-2759	XAP044 CAS No.196928-50-4	XAP044/CAS No.196928-50-4 is a potent and selective antagonist of mGlu7. The metabotropic glutamate receptor subtype 7 (mGlu7) is an important presynaptic regulator of neurotransmission in the mammalian CNS. XAP044 demonstrates good brain exposure and wide spectrum anti-stress and antidepressant- and anxiolytic-like efficacy in rodent behavioral paradigms.	price>
R-R-2760	(±)-LY367385 CAS No.198419-90-8	(±)-LY367385/CAS No.198419-90-8 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a.	price>
R-C-1061	AC55541 CAS：916170-19-9	AC-55541 is a highly selective protease-activated receptor 2(PAR2)agonist (pEC50=6.7),displays no activity at other PAR subtypes or at over 30 other receptors involved in nociception and inflammation.	price>
R-R-2761	Ro 67-4853 CAS No.302841-89-0	Ro 67-4853/CAS No.302841-89-0 is a positive allosteric modulator (PAM) of mGluR1 (pEC50=7.16 for rmGlu1a receptor). Ro67-4853 exhibits activity at all group I mGlu receptors including hmGlu1, rmGlu1, and rmGlu5. Ro 67-4853 enhances the potency of L-Glu by interacting with the transmembrane domain (TMD) of the receptor. Ro 67-4853 potentiates sensory synaptic responses to repetitive vibrissa stimulation.	price>
R-C-1062	ZK-811752(BX-471) CAS:217645-70-0	BX471(ZK-811752)is an orally active, potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM,and exhibits 250-fold selectivity for CCR1 over CCR2,CCR5 and CXCR4.	price>
R-R-2762	TC-N 22A CAS No.1314140-00-5	TC-N 22A/CAS No.1314140-00-5 is a potent, selective, orally active and brain-permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4-expressing BHK cells. TC-N 22A is less active (EC50>10 μM) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC-N 22A has the potential for research of CNS disease in vivo.	price>
R-R-2763	O-Phospho-L-serine-13C3,15N CAS No.2734706-69-3	O-Phospho-L-serine-13C3,15N/CAS No.2734706-69-3 is the 13C- and 15N-labeled O-Phospho-L-serine. O-Phospho-L-serine is the immediate precursor to L-serine in the serine synthesis pathway, and an agonist at the group III mGluR receptors (mGluR4, mGluR6, mGluR7, and mGluR8); O-Phospho-L-serine also acts as a weak antagonist for mGluR1 and a potent antagonist for mGluR2.	price>

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