Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2772	ZJ43 CAS No.723331-20-2	ZJ43/CAS No.723331-20-2 is a potent NAAG peptidase inhibitor, with an IC50 of 2.4 nM and a Ki of 0.8 nM. ZJ43 sufficiently activates group II mGluR and reduces some of the behavioral effects of PCP. ZJ43 shows an analgesic effect in neuropathic and inflammatory and pain models.	price>
R-R-2773	FEMA 4774 CAS No.1359963-68-0	FEMA 4774/CAS No.1359963-68-0 is a positive allosteric modulator of taste receptors T1R2 and T1R3, two subunits of the human sweet taste receptor. FEMA 4774 is also used as a sucrose sweetness enhancer.	price>
R-R-2774	Pramlintide acetate CAS No.187887-46-3	Pramlintide acetate/CAS No.187887-46-3 is a polypeptide analogue of human amylin. Pramlintide acetate, an antidiabetic agent, is antineoplastic in colorectal cancer.	price>
R-R-2775	a-CGRP (mouse, rat) (TFA)	α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.	price>
R-R-2776	Cagrilintide acetate	Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies.	price>
R-R-2777	b-CGRP, human TFA	β-CGRP, human TFA (Human β-CGRP TFA) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells.	price>
R-R-2778	Olcegepant hydrochloride CAS No.586368-06-1	Olcegepant hydrochloride (BIBN-4096 hydrochloride)/CAS No.586368-06-1 is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide receptor 1 (CGRP1) with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP.	price>
R-R-2779	Telcagepant CAS No.781649-09-0	Telcagepant (MK-0974)/CAS No.781649-09-0 is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.	price>
R-R-2780	BCTC CAS No.393514-24-4	BCTC/CAS No.393514-24-4 is an orally active current inhibitor of vanilloid receptor type 1 (VR1). BCTC is a transient receptor potential cation channel subfamily M member 8 (TRPM8) and transient receptor potential vanilloid 1 (TRPV1) antagonist. BCTC is an insulin sensitizer and secretor. BCTC has anticancer and analgesic effects.	price>
R-R-2781	MK-3207 CAS No.957118-49-9	MK-3207/CAS No.957118-49-9 is an orally active, highly selective and species-specific CGRP receptor antagonist (for human CGRP receptor: IC50=0.12 nM; Ki=0.024 nM). MK-3207 can be used for migraine studies.	price>

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