Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2725	LSN2463359 CAS No.1401031-52-4	LSN2463359/CAS No.1401031-52-4 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2726	LY2812223 CAS No.1311385-20-2	LY2812223/CAS No.1311385-20-2 is a highly potent, functionally selective mGlu2 receptor agonist with mGlu2 binding affinity for mGlu2 and mGlu3 (Ki=144 nM and 156 nM, respectively).	price>
R-R-2727	LY487379 CAS No.353231-17-1	LY487379/CAS No.353231-17-1 is a selective human mGluR2 positive allosteric modulator (PAM). LY487379 potentiates glutamate-stimulated [35S]GTPγS binding with EC50 values of 1.7 μM and >10 μM for mGlu2 and mGlu3 receptors respectively. LY487379 promotes cognitive flexibility and facilitates behavioral inhibition in a rat model. LY487379 can be used for schizophrenia research.	price>
R-R-2728	E4CPG CAS No.170846-89-6	E4CPG ((RS)-ECPG)/CAS No.170846-89-6 is a Group I/Group II metabotropic glutamate receptor (mGluR) antagonist. E4CPG can inhibit the paired-pulse ratio of monosynaptic inhibitory postsynaptic currents (IPSC) potentiation.	price>
R-R-2729	YM-298198 hydrochloride CAS No.1216398-09-2	YM-298198 hydrochloride/CAS No.1216398-09-2 is a high-affinity, selective, orally active, and non-competitive antagonist of metabotropic glutamate receptor type 1 (mGluR1). YM-298198 hydrochloride can be used for the research of neurological disorders.	price>
R-R-2730	FTIDC CAS No.873551-53-2	FTIDC/CAS No.873551-53-2 is an orally active, noncompetitive, selective allosteric metabotropic glutamate receptor (mGluR) 1 antagonist with an IC50 of 5.8 nM for human mGluR1a. FTIDC has no species differences in its antagonistic activity on recombinant human, mouse, and rat mGluR1.	price>
R-R-2731	LY2979165 CAS No.1311385-32-6	LY2979165/CAS No.1311385-32-6 is the alanine proagent of 2812223, a selective and potent orthosteric mGlu2 receptor agonist.	price>
R-R-2732	CPPHA CAS No.693288-97-0	CPPHA/CAS No.693288-97-0 is potent and selective positive allosteric modulator (PAM) of the mGluR5 and mGluR1 (metabotropic glutamate receptor). CPPHA can potentiate responses of mGluR5 and mGluR1 to activation of these receptors. CPPHA is developed for the research of central nervous system disorders.	price>
R-R-2733	BMT-145027 CAS No.2018282-44-3	BMT-145027/CAS No.2018282-44-3 is an mGluR5 positive allosteric modulator without inherent agonist activity, exhibits an EC50 of 47 nM.	price>
R-R-2734	Valiglurax CAS No.1976050-09-5	Valiglurax (VU0652957)/CAS No.1976050-09-5 is a potent, orally active and selective mGlu4 positive allosteric modulator with EC50 values of 64.6 nM and 197 nM for hmGlu4/Gqi5 and rmGlu4 GIRK, respectively. Valiglurax is a central nervous system (CNS) penetrant.	price>

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