Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2715	(1R,2S)-VU0155041 CAS No.1263273-14-8	(1R,2S)-VU0155041/CAS No.1263273-14-8, Cis regioisomer of VU0155041, is a partial mGluR4 agonist with an EC50 of 2.35 μM.	price>
R-R-2716	AZD-8529 mesylate CAS No.1314217-69-0	AZD-8529 mesylate/CAS No.1314217-69-0 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.	price>
R-R-2717	ML353	ML353 is a selective ligand of mGlu5 silent allosteric modulator (SAM) with an Ki value of 18.2 nM. ML353 improves the affinity of common allosteric sites, 20-fold higher than the previous mGlu5 SAM tool compound 5mpep. ML353 has potential applications in solving the intrinsic activity of SAM in vivo or as a agent blocker. ML353 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2718	CFMTI CAS No.864864-17-5	CFMTI/CAS No.864864-17-5 inhibits L-glutamate-induced intracellular Ca2+ mobilization in CHO cells expressing human and rat mGluR1a, with IC50s of 2.6 and 2.3 nM, respectively.	price>
R-R-2719	(S)-3,4-DCPG CAS No.201730-11-2	(S)-3,4-DCPG/CAS No.201730-11-2 is a selective agonist of metabotropic glutamate receptor 8a (mGluR8a) with an EC50 of 31 nM in AV12-664 cells expressing human mGluR8.	price>
R-R-2720	Oxomemazine CAS No.3689-50-7	Oxomemazine/CAS No.3689-50-7 is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic properties. Oxomemazine is a selective antagonist for muscarinic M1 receptor, displays about 20-fold difference in the affinity for high (Ki = 84 nM, M1 receptor) and low (Ki = 1.65 μM, M2 receptor) affinity sites. Oxomemazine an antihistamine and anticholinergic agent used for the study of cough treatment.	price>
R-R-2721	(R)-ADX-47273 CAS No.851881-59-9	(R)-ADX-47273/CAS No.851881-59-9 is a potent mGluR5 positive allosteric modulator, with an EC50 of 168 nM for potentiation .	price>
R-R-2722	VU0155041 CAS No.1093757-42-6	VU0155041/CAS No.1093757-42-6 is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively.	price>
R-R-2723	VU0483605 CAS No.1623101-11-0	VU0483605/CAS No.1623101-11-0 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM). VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively.	price>
R-R-2724	AZ 12216052 CAS No.1290628-31-7	AZ 12216052/CAS No.1290628-31-7 is a mGluR8 positive allosteric modulator, and helps mGluR8 modulate signaling inputing to retinal ganglion cells. AZ 12216052 exhibits antianxiety effect.	price>

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