Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2696	Decoglurant CAS No.911115-16-7	Decoglurant (RO4995819)/CAS No.911115-16-7 is a negative allosteric modulator of mGluR2 and mGluR3. Decoglurant is developed as an antidepressant.	price>
R-R-2697	Ro 01-6128 CAS No.302841-86-7	Ro 01-6128/CAS No.302841-86-7 is a positive allosteric modulator of mGluR1.	price>
R-R-2698	VU0422288 CAS No.1630936-95-6	VU0422288 (ML396)/CAS No.1630936-95-6 is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.	price>
R-R-2699	CVN636 CAS No.2226732-62-1	CVN636/CAS No.2226732-62-1 is a potent, orally active and selective mGluR7 allosteric agonist with an EC50 value of 7 nM for hu mGluR7. CVN636 has central nervous system (CNS) permeability.	price>
R-R-2700	trans-ACPD CAS No.67684-64-4	trans-ACPD/CAS No.67684-64-4, a metabotropic receptor agonist, produces calcium mobilization and an inward current in cultured cerebellar Purkinje neurons.	price>
R-R-2701	FPTQ CAS No.864863-72-9	FPTQ/CAS No.864863-72-9 is potent mGluR1 antagonist with IC50 values of 6 nM and 1.4 nM for human and mouse mGluR1 respectively. FPTQ has anti-oxidant and anti-inflammatory effects in vitro and in vivo.	price>
R-R-2702	ML337 CAS No.1443118-44-2	ML337/CAS No.1443118-44-2 is a selective and brain-penetrant negative allosteric modulator of mGlu3, with an IC50 of 593 nM. ML337 possesses a favorable dystrophia myotonica protein kinase (DMPK) and ancillary pharmacology profile. ML337 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-2703	JNJ-46281222 CAS No.1254980-38-5	JNJ-46281222/CAS No.1254980-38-5 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator) with nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).	price>
R-C-1004	Empaglifilozin(BI-10773)	Empagliflozin is a potent,selective sodium glucose co-transporter-2 inhibitor that is in development for the treatment of type 2 diabetes.	price>
R-R-2704	L-Glutamine-13C5,15N2 CAS No.285978-14-5	L-Glutamine-13C5,15N2/CAS No.285978-14-5 is the 13C- and 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>

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