Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2686	LY3020371 hydrochloride CAS No.1377615-44-5	LY3020371 hydrochloride/CAS No.1377615-44-5 is a potent, selective metabotropic glutamate 2/3 receptor (mGlu2/3) antagonist with Ki of 5.3 and 2.5 nM, potently blocks cAMP formation with IC50 of 16.2 nM. LY3020371 hydrochloride exerts an antidepressant-like signature in vivo.	price>
R-R-2687	(S)-3,5-DHPG CAS No.162870-29-3	(S)-3,5-DHPG/CAS No.162870-29-3 is a weak, but selective group I metabotropic glutamate receptors (mGluRs) agonist with Ki values of 0.9 µM and 3.9 µM for mGluR1a and mGluR5a, respectively. (S)-3,5-DHPG exhibits anxiolytic activity in rats subjected to hypoxia.	price>
R-R-2688	L-Cysteinesulfinic acid CAS No.1115-65-7	L-Cysteinesulfinic acid/CAS No.1115-65-7 is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.	price>
R-R-2689	DL-AP3 CAS No.5652-28-8	DL-AP3/CAS No.5652-28-8 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect.	price>
R-R-2690	CPPG CAS No.183364-82-1	CPPG ((RS)-CPPG)/CAS No.183364-82-1 is a potent group II/III mGlu receptors antagonist. CPPG exhibits some selectivity (approximately 20 fold) for group III (IC50=2.2 nM) over group II (IC50=46.2 nM) mGlu receptors in the rat cerebral cortex. CPPG has weak effects at group I mGlu receptors.	price>
R-R-2691	Quisqualic acid CAS No.52809-07-1	Quisqualic acid (L-Quisqualic acid)/CAS No.52809-07-1, a natural analog of glutamate, is a potent and pan two subsets (iGluR and mGluR) of excitatory amino acid (EAA) agonist with an EC50 of 45 nM and a Ki of 10 nM for mGluR1R. Quisqualic acid is isolated from the fruits of Quisqualis indica.	price>
R-R-2692	BMS-984923 CAS No.1375752-78-5	BMS-984923/CAS No.1375752-78-5, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.	price>
R-R-2693	CALP1 TFA	CALP1 TFA is a calmodulin (CaM) agonist (Kd of 88 µM) with binding to the CaM EF-hand/Ca2+-binding site. CALP1 TFA blocks calcium influx and apoptosis (IC50 of 44.78 µM) through inhibition of calcium channel opening. CALP1 TFA blocks glutamate receptor channels and blocks a store-operated nonselective cation channel. CALP1 TFA activates CaM-dependent phosphodiesterase activity.	price>
R-R-2694	Fenobam CAS No.57653-26-6	Fenobam/CAS No.57653-26-6 is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.	price>
R-R-2695	UPF-523 CAS No.168560-79-0	UPF-523 (AIDA)/CAS No.168560-79-0, a rigid (carboxyphenyl) glycine derivative, is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a) with an IC50 of 214 μM. But UPF-523 has no effect on group II (mGlu2), group III (mGlu4) receptors or ionotropic glutamate receptors. UPF-523 has the potential for the research of the acute arthritis.	price>

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