Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-2677	CDPPB CAS No.781652-57-1	CDPPB/CAS No.781652-57-1 is a potent, selective and brain penetrant positive allosteric modulator of the metabotropic glutamate receptor subtype 5 (mGluR5), with an EC50 of 27 nM in Chinese hamster ovary cells expressing human mGluR5. CDPPB may provide an approach for development of antipsychotic agents.	price>
R-C-978	PP1 (Src Inhibitor) cas:172889-26-8	PP 1 is a selective and potent Src family tyrosine kinase inhibitor.PP 1 studies have proved its ability to potently inhibit Lck and Fyn(FynT),IL-2 gene activation in T lymphocytes,and anti-CD3-induced protein tyrosine phosphorylation.Research indicates that PP 1 effectively blocks LPA and EGF-enhanced tyrosine phosphorylation,MAPK activation downstream of EGFR,Rsk-1 (p90RSK)activation by H2O2,Kit and Bcr-Abl tyrosine kinases,and degrades RETMEN2A and RETMEN2B oncoproteins via proteosomal targeting.Rat basophilic leukemia cell studies have shown that PP1 inhibits Fc εRI- and Thy-1-mediated activation.Structural studies have revealed that PP1 binds to the ATP-binding site in tyrosine kinases and Ser/Thr kinases.	price>
R-R-2678	JNJ-40411813 CAS No.1127498-03-6	JNJ-40411813 (ADX-71149)/CAS No.1127498-03-6 is a novel positive allosteric modulator of the metabotropic Glutamate 2 receptor (mGlu2R) with EC50 of 147 nM. JNJ-40411813 has orally bioactivity and penetrate the blood-brain barriers. JNJ-40411813 has the potential property of anti-depression.	price>
R-R-2679	AMN082 CAS No.97075-46-2	AMN082/CAS No.97075-46-2, a selective, orally active, and brain penetrant mGluR7 agonist, directly activates receptor signaling via an allosteric site in the transmembrane domain. AMN082 potently inhibits cAMP accumulation and stimulates GTPγS binding (EC50 values, 64-290 nM) at transfected mammalian cells expressing mGluR7. AMN082 shows selectivity over other mGluR subtypes and selected ionotropic glutamate receptors. Antidepressant effects.	price>
R-R-2680	L-Glutamine-1-13C CAS No.159663-16-8	L-Glutamine-1-13C/CAS No.159663-16-8 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-R-2681	VU6005649 CAS No.2137047-43-7	VU6005649/CAS No.2137047-43-7 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0.65 μM and 2.6 μM for mGlu7 receptor and mGlu8 receptor, respectively.	price>
R-R-2682	L-Glutamine-d5 CAS No.14341-78-7	L-Glutamine-d5/CAS No.14341-78-7 is the deuterium labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-R-2683	L-Glutamine-15N2 CAS No.204451-48-9	L-Glutamine-15N2/CAS No.204451-48-9 is the 15N-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.	price>
R-R-2684	VU6012962 CAS No.2313526-86-0	VU6012962/CAS No.2313526-86-0 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator (mGlu7 NAM) with an IC50 of 347 nM.	price>
R-R-2685	AZD-8529 CAS No.1092453-15-0	AZD-8529/CAS No.1092453-15-0 is a potent, highly selective and orally bioavailable positive allosteric modulator of mGluR2, with an EC50 of 285 nM, and shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.	price>

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