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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4168 C-021 CAS No.864289-85-0 C-021/CAS No.864289-85-0 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM. price>
R-R-4169 Tivumecirnon CAS No.2174938-78-2 Tivumecirnon (FLX475)/CAS No.2174938-78-2 is an orally active CCR4 antagonist that blocks regulatory T cells from entering the tumor microenvironment, thereby reducing their interference with effective anti-tumor immune responses. Tivumecirnon has antitumor activity. price>
R-R-4170 CCR2 antagonist 4 hydrochloride CAS No.1313730-14-1 CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride)/CAS No.1313730-14-1 is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM. price>
R-R-4171 K777 CAS No.233277-99-1 K777/CAS No.233277-99-1 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively. price>
R-R-4172 Cenicriviroc Mesylate CAS No.497223-28-6 Cenicriviroc Mesylate (TAK-652 Mesylate)/CAS No.497223-28-6 is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2, and displays potent anti-inflammatory and antiinfective activity. price>
R-R-4173 BMS-813160 CAS No.1286279-29-5 BMS-813160/CAS No.1286279-29-5 is a potent and selective CCR2/5 dual antagonist. BMS-813160 binds with CCR2 and CCR5 with IC50s of 6.2 and 3.6 nM, respectively. BMS-813160 can be used for the research of inflammation. price>
R-C-2474 Flavoxate HCl CAS:3717-88-2 Flavoxate Hydrochloride(DW-61 Hydrochloride)is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic. price>
R-R-4174 J-113863 CAS No.353791-85-2 J-113863/CAS No.353791-85-2 is a potent and selective CCR1 antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. price>
R-R-4175 Vercirnon CAS No.698394-73-9 Vercirnon (GSK1605786A)/CAS No.698394-73-9 is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively. price>
R-R-4176 CCR7 Ligand 1 CAS No.681514-83-0 CCR7 Ligand 1 (CCR7-Cmp2105)/CAS No.681514-83-0 is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. price>