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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4160 CCR6 antagonist 1 CAS No.588674-64-0 CCR6 antagonist 1/CAS No.588674-64-0 is a CCR6 antagonist that inhibits the CCL20/CCR6 axis. CCR6 antagonist 1 can be used in the research of autoimmune-mediated inflammatory diseases, such as inflammatory bowel diseases (IBDs). price>
R-R-4161 CCR6 inhibitor 1 CAS No.2437547-04-9 CCR6 inhibitor 1/CAS No.2437547-04-9 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer. price>
R-R-4162 AZD2098 CAS No.566203-88-1 AZD2098/CAS No.566203-88-1 is a potent and selective CC-chemokine receptor 4 (CCR4) inhibitor with pIC50s of 7.8, 8.0, 8.0 and 7.6 for human, rat, mouse and dog respectively, used for asthma research. price>
R-R-4163 ZK756326 dihydrochloride CAS No.1780259-94-0 ZK756326 dihydrochloride/CAS No.1780259-94-0 is a nonpeptide chemokine receptor agonist for the CC chemokine receptor CCR8. price>
R-R-4164 AZ084 CAS No.929300-19-6 AZ084/CAS No.929300-19-6 is a potent, selective, allosteric and oral active CCR8 allosteric antagonist, with a Ki of 0.9 nM. Has potential to treat asthma. AZ084 restrains the formation of the immunologically tolerant pre-metastatic niche (PMN) and tumor cells metastasis in lung by downregulating Treg differentiation. AZ084 can be used in studies of asthma and cancer. price>
R-R-4165 BX471 hydrochloride CAS No.288262-96-4 BX471 hydrochloride (ZK-811752 hydrochloride)/CAS No.288262-96-4 is a potent, selective non-peptide CCR1 antagonist with Ki of 1 nM for human CCR1, and exhibits 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. price>
R-R-4166 R243 CAS No.688352-84-3 R243/CAS No.688352-84-3 is a potent and selective CCR8 antagonist. R243 inhibits CCL1/CCR8 interaction and inhibits CCR8 signaling and chemotaxis. R243 has antinociceptive and anti-inflammatory effects. price>
R-R-4167 GW 766994 CAS No.408303-43-5 GW 766994 (GW 994)/CAS No.408303-43-5 is a chemokine receptor-3 (CCR3) antagonist that is orally active and specific. GW 766994 has the potential for research into asthma and eosinophilic bronchitis. price>
R-R-4168 C-021 CAS No.864289-85-0 C-021/CAS No.864289-85-0 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM. price>
R-R-4169 Tivumecirnon CAS No.2174938-78-2 Tivumecirnon (FLX475)/CAS No.2174938-78-2 is an orally active CCR4 antagonist that blocks regulatory T cells from entering the tumor microenvironment, thereby reducing their interference with effective anti-tumor immune responses. Tivumecirnon has antitumor activity. price>