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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4174 J-113863 CAS No.353791-85-2 J-113863/CAS No.353791-85-2 is a potent and selective CCR1 antagonist with IC50 values of 0.9 nM and 5.8 nM for human and mouse CCR1 receptors, respectively. J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptors. Anti-inflammatory effect. price>
R-R-4175 Vercirnon CAS No.698394-73-9 Vercirnon (GSK1605786A)/CAS No.698394-73-9 is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively. price>
R-R-4176 CCR7 Ligand 1 CAS No.681514-83-0 CCR7 Ligand 1 (CCR7-Cmp2105)/CAS No.681514-83-0 is an allosteric Ligand and antagonist for human CC chemokine receptor 7 (CCR7) with a Kd of 3 nM. CCR7 Ligand 1, thiadiazole-dioxide ligan, suppresses arrestin binding in response to activation by CCL19 with an IC50 of 7.3 μM. price>
R-R-4177 BI-6901 CAS No.2040401-92-9 BI 6901/CAS No.2040401-92-9 is a potent, selective CCR10 antagonist (pIC50=9.0). BI 6901 shows high selectivity over other GPCRs, including a number of other chemokine receptors. BI 6901 is efficacious in the murine DNFB model of contact hypersensitivity and can be used for inflammation research. price>
R-R-4178 INCB 3284 CAS No.887401-92-5 INCB 3284/CAS No.887401-92-5 is a potent, selective and orally bioavailable human CCR2 antagonist, inhibiting monocyte chemoattractant protein-1 binding to hCCR2, with an IC50 of 3.7 nM. INCB 3284 can be used in the research of acute liver failure. price>
R-R-4179 MK-0812 Succinate CAS No.851916-42-2 MK-0812 Succinate/CAS No.851916-42-2 is a potent and selective CCR2 antagonist with high affinity at CCR2. price>
R-R-4180 SB-328437 CAS No.247580-43-4 SB-328437/CAS No.247580-43-4 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM. price>
R-R-4181 ML604086 CAS No.850330-18-6 ML604086/CAS No.850330-18-6 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations. price>
R-R-4182 ALK4290 CAS No.1251528-23-0 ALK4290 (AKST4290)/CAS No.1251528-23-0 is a potent and orally active CCR3 inhibitor extracted from patent US20130261153A1, compound Example 2, with a Ki of 3.2 nM for hCCR3. ALK4290 can be used for the research of neovascular age-related macular degeneration and Parkinsonism. price>
R-R-4183 PF-07054894 CAS No.2413693-96-4 PF-07054894/CAS No.2413693-96-4 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease. price>