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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4187 GSK2239633A CAS No.1240516-71-5 GSK2239633A/CAS No.1240516-71-5 is a CC-chemokine receptor 4 (CCR4) antagonist, which inhibits the binding of [125I]-TARC to human CCR4 with a pIC50 of 7.96 ± 0.11. price>
R-R-4188 LMD-009 CAS No.950195-51-4 LMD-009/CAS No.950195-51-4 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM. price>
R-R-4189 RS102895 CAS No.300815-41-2 RS102895/CAS No.300815-41-2 is a potent CCR2 antagonist, with an IC50 of 360 nM, and shows no effect on CCR1. price>
R-R-4190 CCR2-RA-[R] CAS No.512177-83-2 CCR2-RA-[R]/CAS No.512177-83-2 is an allosteric antagonist of the C-C chemokine receptor type 2 (CCR2) with an IC50 of 103 nM. price>
R-R-4191 TAK-220 CAS No.333994-00-6 TAK-220/CAS No.333994-00-6 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs. price>
R-R-4192 BI 639667 CAS No.1295298-26-8 BI 639667 (compound 19n)/CAS No.1295298-26-8, a third azaindazole series compound, is a CCR1 antagonist, with an IC50 of 1.8 nM in Ca2+ flux assay. price>
R-R-4193 YM022 CAS No.145084-28-2 YM022/CAS No.145084-28-2 is a highly potent, selective and orally active gastrin/cholecystokinin (CCK)-B receptor (CCK-BR) antagonist. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. price>
R-R-4194 CCR8 antagonist 1 CAS No.723304-76-5 CCR8 antagonist 1 (compound 15)/CAS No.723304-76-5 is a potente human CCR8 antagonist with a Ki of 1.6 nM. price>
R-R-4195 Vicriviroc maleate CAS No.599179-03-0 Vicriviroc maleate (SCH-417690 maleate; SCH-D maleate)/CAS No.599179-03-0 is a potent, selective, oral bioavailable and CNS penetrated antagonist of CCR5, with a Ki of 2.5 nM, and also inhibits HIV-1 in PBMC cells, with IC90s of 3.3 nM (JrFL), 2.8 nM (ADA-M), 1.8 nM (301657), 4.9 nM (JV1083) and 10 nM (RU 570). price>
R-R-4196 CCR1 antagonist 9 CAS No.1220026-26-5 CCR1 antagonist 9/CAS No.1220026-26-5 is a potent and selective CCR1 antagonist with an IC50 of 6.8 nM in calcium flux assay. price>