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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4204 CKLF1-C19 CAS No.960358-79-6 CKLF1-C19/CAS No.960358-79-6 is the C-terminal peptide of human chemokine-like factor 1 (CKLF1). CKLF1-C19 interacts with CCR4, and inhibits chemotaxis induced by both CKLF1 and CCL17. CKLF1-C19 can suppress allergic lung inflammation via inhibiting chemotaxis mediated by CCR3 and CCR4. price>
R-R-4205 C-021 dihydrochloride CAS No.1784252-84-1 C-021 dihydrochloride/CAS No.1784252-84-1 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM. price>
R-R-4206 Vercirnon sodium CAS No.886214-18-2 Vercirnon (GSK1605786A) sodium/CAS No.886214-18-2 is an orally bioavailable, selective, and potent antagonist of CCR9. Vercirnon sodium inhibits CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells with IC50 values of 5.4 and 3.4 nM, respectively. Vercirnon sodium is selective for CCR9 over CCR1-12 and CX3CR1-7 (IC50s>10 µM for all). Vercirnon sodium is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50 values of 2.8 and 2.6 nM, respectively. price>
R-R-4207 CCR4 antagonist 4 CAS No.668980-17-4 CCR4 antagonist 4 (compound 22)/CAS No.668980-17-4 is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research. price>
R-R-4208 Nifeviroc CAS No.934740-33-7 Nifeviroc/CAS No.934740-33-7 is an orally active CCR5 antagonist. Nifeviroc is used for the study of HIV type-1 infection. price>
R-R-4209 CCR2 antagonist 4 CAS No.226226-39-7 CCR2 antagonist 4 (Teijin compound 1)/CAS No.226226-39-7 is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM. price>
R-R-4210 Aplaviroc hydrochloride CAS No.461023-63-2 Aplaviroc (AK 602) hydrochloride/CAS No.461023-63-2, a SDP derivative, is a CCR5 antagonist, with IC50s of 0.1-0.4 nM for HIV-1Ba-L, HIV-1JRFL and HIV-1MOKW. price>
R-R-4211 AZD-1678 CAS No.942137-41-9 AZD-1678/CAS No.942137-41-9 is a potent CCR4 receptor antagonist, with a pIC50 of 8.6. price>
R-R-4212 CCR4 antagonist 3 CAS No.1957-01-3 CCR4 antagonist 3/CAS No.1957-01-3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC50 value of 1.7 μM for [125I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 μM). price>
R-R-4213 CCX354 CAS No.1010073-75-2 CCX354/CAS No.1010073-75-2 is an antagonist of CCR1, with anti-inflammatory activity. price>