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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4214 CCR4-351 hydrochloride CAS No.2174938-71-5 CCR4-351 hydrochloride/CAS No.2174938-71-5 is an orally active, potent and selective CCR4 antagonist. CCR4-351 hydrochloride, featuring a novel piperidinyl-azetidine motif, has IC50s of 22 nM and 50 nM in the calcium flux and CTX assay. CCR4-351 hydrochloride has antitumor activity. price>
R-R-4215 INCB3344 R-isomer INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. price>
R-R-4216 BMS-817399 CAS No.1202400-18-7 BMS-817399/CAS No.1202400-18-7 is a potent, selective, and orally bioavailable CCR1 antagonist. BMS-817399 exhibits CCR1 binding affinity and chemotaxis inhibition potencies of 1 and 6 nM (IC50), respectively. BMS-817399 can be used for the research of rheumatoid arthritis. price>
R-R-4217 CCR3 antagonist 1 CAS No.879399-82-3 CCR3 antagonist 1/CAS No.879399-82-3 is a potent antagonist of CCR3, used for the research of immunologic and inflammatory diseases. price>
R-R-4218 Maraviroc-d6 CAS No.1033699-22-7 Maraviroc-d6 (UK-427857-d6)/CAS No.1033699-22-7 is the deuterium labeled Maraviroc. Maraviroc (UK-427857) is a selective CCR5 antagonist with activity against human HIV. price>
R-R-4219 CKLF1-C27 CAS No.891861-48-6 CKLF1-C27/CAS No.891861-48-6, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research. price>
R-R-4220 α-NETA CAS No.115066-04-1 α-NETA/CAS No.115066-04-1 is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity. price>
R-R-4221 Devazepide CAS No.103420-77-5 Devazepide (L-364,718)/CAS No.103420-77-5 is a potent, competitive, selective and orally active nonpeptide antagonist of cholecystokinin (CCK) receptor, with IC50s of 81 pM, 45 pM and 245 nM for rat pancreatic, bovine gallbladder and guinea pig brain CCK receptors, respectively. Devazepide (L-364,718) is effective for gastrointestinal disorders. price>
R-R-4222 Sograzepide CAS No.155488-25-8 Sograzepide (Netazepide; YF 476; YM-220)/CAS No.155488-25-8 is an extremely potent , highly selective and orally active Gastrin/CCK-B antagonist with an IC50 value of 0.1 nM, has inhibitory effect on Gastrin/CCK-A activity with an IC50 of 502 nM. Sograzepide (Netazepide; YF 476; YM-220) replaces the specific binding of [125I]CCK-8 to the rat brain, cloned canine and cloned human Gastrin/CCK-B receptors, with Ki values of 0.068, 0.62 and 0.19 nM, respectively. price>
R-R-4223 L-365260 CAS No.118101-09-0 L-365260/CAS No.118101-09-0 is an orally active and selective antagonist of non-peptide gastrin and brain cholecystokinin receptor (CCK-B), with Kis of 1.9 nM and 2.0 nM, respectively. L-365260 interacts in a stereoselective and competitive manner with guinea pig stomach gastrin and brain CCK receptors. L-365260 can enhance Morphine analgesia and prevents Morphine tolerance. price>