Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4596	IMP-1088 CAS No.2059148-82-0	IMP-1088/CAS No.2059148-82-0 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection.	price>
R-R-4597	CX-5461 dihydrochloride	CX-5461 dihydrochloride is a potent and orally bioavailable inhibitor of Pol I-mediated rRNA synthesis, with IC50s of 142 nM in HCT-116, 113 nM in A375, and 54 nM in MIA PaCa-2 cells, and shows little or no effect on Pol II (IC50 ≥25 μM).	price>
R-R-4598	Tirapazamine CAS No.27314-97-2	Tirapazamine (SR259075)/CAS No.27314-97-2 is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells.	price>
R-R-4599	RP-6685 CAS No.2832047-80-8	RP-6685/CAS No.2832047-80-8 is a potent, selective and orally active DNA polymerase theta (Polθ) inhibitor with an IC50 value of 5.8 nM (PicoGreen assay). RP-6685 shows antitumor efficacy in mouse tumor xenograft model. RP-6685 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-4600	D-I03 CAS No.688342-78-1	D-I03/CAS No.688342-78-1 is a selective RAD52 inhibitor with a Kd of 25.8 µM. D-I03 specifically inhibits RAD52-dependent single-strand annealing (SSA) and D-loop formation with IC50s of 5 µM and 8 µM, respectively. D-I03 suppresses growth of BRCA1- and BRCA2-deficient cells and inhibits formation of damage-induced RAD52 foci, but does not effect on RAD51 foci induced by Cisplatin.	price>
R-R-4601	Quarfloxin CAS No.865311-47-3	Quarfloxin (CX-3543)/CAS No.865311-47-3, a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template.	price>
R-R-4602	Nusinersen CAS No.1258984-36-9	Nusinersen/CAS No.1258984-36-9 is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein.The free form of the compound is prone to instability, it is advisable to consider the stable salt form (Nusinersen sodium) that retains the same biological activity.	price>
R-R-4603	GS-443902 trisodium CAS No.1355050-21-3	GS-443902 trisodium (GS-441524 triphosphate trisodium)/CAS No.1355050-21-3 is a potent viral RNA-dependent RNA-polymerases (RdRp) inhibitor with IC50s of 1.1 µM, 5 µM for RSV RdRp and HCV RdRp, respectively. GS-443902 trisodium is the active triphosphate metabolite of Remdesivir (GS-5734).	price>
R-R-4604	Fidaxomicin CAS No.873857-62-6	Fidaxomicin (OPT-80)/CAS No.873857-62-6, a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.	price>
R-R-4605	Cytarabine hydrochloride CAS No.69-74-9	Cytarabine hydrochloride/CAS No.69-74-9, a nucleoside analog, causes S phase cell cycle arrest and inhibits DNA polymerase. Cytarabine inhibits DNA synthesis with an IC50 of 16 nM. Cytarabine hydrochloride has antiviral effects against HSV.	price>

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